Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population

Table 1 Comparison of IL-18 gene promoter polymorphism between patients with chronic hepatitis B and controls.

Polymorphism	Control n = 300 (%)	Patient n = 231 (%)	χ2	P
Position -607
Genotypes
CC	66 (22.0)	62 (26.8)	1.67	0.196
CA	160 (53.3)	116 (50.2)	0.51	0.476
AA	74 (24.7)	53 (23.0)	0.21	0.645
Alleles
C	292 (48.7)	240 (51.9)	1.12	0.842
A	308 (51.3)	222 (48.1)
Position -137
Genotypes
GG	202 (67.3)	182 (78.8)	8.55	0.003
GC	90 (30.0)	45 (19.5)	7.62	0.006
CC	8 (2.7)	4 (1.7)	0.52	0.472
Alleles
G	494 (82.3)	409 (88.5)	7.87	0.005
C	106 (17.7)	53 (11.5)

Table 2 Haplotype frequencies of two interleukin-18 bi-allelic polymorphisms in chronic hepatitis B and health controls.

Haplotype	-607C/A	-137G/C	Control n (%)	Patient n (%)	χ2	P
I	C	G	284 (47.4)	239(51.7)	2.02	0.155
II	C	C	8 (1.3)	1 (0.2)	3.87	0.049
III	A	G	210 (35.0)	170 (36.8)	0.37	0.545
IV	A	C	98 (16.3)	52 (11.3)	5.55	0.018
Total			600	462

Table 3 The association between genotypes of IL-18 promoter region polymorphisms and HBV copies in the chronic hepatitis B patients.

Polymorphism	Group I n = 97 (%)	Group II n = 134 (%)	χ2	P
Position -607
Genotypes
CC	23 (23.7)	39 (29.1)	0.83	0.361
CA	44 (45.4)	72 (53.7)	1.58	0.209
AA	30 (30.9)	23 (17.2)	6.03	0.014
Alleles
C	90 (46.4)	150 (56.0)	4.14	0.042
A	104 (53.6)	118 (44.0)
Position -137
Genotypes
GG	76 (78.4)	106(79.1)	0.021	0.89
GC	20 (20.6)	25 (18.7)
CC	1 (1.0)	3 (2.2)
Alleles
G	172 (88.7)	237 (88.4)	0.01	0.94
C	22 (11.3)	31 (11.6)

Group I: HBV-DNA <1×10³ copies/mL; Group II: HBV-DNA ≥1×10³ copies/mL. GG compared with both GC and CC.