Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils

doi:10.3748/wjg.v11.i1.104

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Jan 7, 2005 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

H Pylori

World J Gastroenterol. Jan 7, 2005; 11(1): 104-108
Published online Jan 7, 2005. doi: 10.3748/wjg.v11.i1.104

Table 1 Changes of gastric inflammation induced by indomethacin between H pylori infected, H pylori-eradicated and H pylori-uninfected gerbils (mean±SD).

H pylori-infected	H pylori-eradicated	H pylori-uninfected	P
Stomach weight ratio (×1000)	14.1±1.3	10.5±0.3	9.0±0.3	<0.05^a
				<0.05^c
Hyperplasia area (mm²)	82.4±9.2	13.9±3.5	0	<0.05^a
				<0.05^c
Erosion and ulcer area (mm²)	14.4±4.9	0.9±0.5	0	<0.05^a
				<0.05^c
Score of gastritis	7.0±0.0	3.6±0.5	0.8±0.4	<0.05^a
				<0.05^c
MPO activity (mmoL H₂O₂/min/g tissue)	104.7±9.2	8.9±2.3	7.8±2.5	<0.05^a
				<0.05^c
PGE₂ synthesis (pg/mg wet weight/min)	299.2±81.5	102.8±26.2	9.6±1.3	<0.05^a
				<0.05^c

Stomach weight ratio: weight of stomach to weight of body ^aP<0.05, H pylori-infected vs H pylori-eradicated; ^cP<0.05, H pylori- infected vs H pylori uninfected.

Table 2 Changes of gastric inflammation induced by rofecoxib between H pylori-infected, H pylori-eradicated and H pylori-uninfected gerbils.

H pylori-infected	H pylori-eradicated	H pylori-uninfected	P
Stomach weight ratio (×1000)	12.8±0.4	10.1±0.3	8.1±0.4	<0.05^a
				<0.05^c
Hyperplasia area (mm²)	30.5±5.1	1.3±0.6	0	<0.05^a
				<0.05^c
Erosion and ulcer area (mm²)	1.3±0.6	0.4±0.3	0	<0.05^a
				<0.05^c
Score of gastritis	7.0±0.0	2.7±0.5	0	<0.05^a
				<0.05^c
MPO activity (mmoL H₂O₂/min/g tissue)	133.5±15.0	2.9±0.7	6.6±1.7	<0.05^a
				<0.05^c
PGE₂ synthesis (pg/mg wet weight/min)	321.4±30.3	11.9±4.8	25.9±15.9	<0.05^a
				<0.05^c

Stomach weight ratio: weight of stomach to weight of body ^aP<0.05, H pylori-infected vs H pylori-eradicated; ^cP<0.05, H pylori- infected vs H pylori uninfected.

Citation: Chang CC, Chen SH, Lien GS, Lou HY, Hsieh CR, Fang CL, Pan S. Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. World J Gastroenterol 2005; 11(1): 104-108
URL: https://www.wjgnet.com/1007-9327/full/v11/i1/104.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i1.104