Significance of effector protease receptor-1 expression and its relationship with proliferation and apoptotic index in patients with primary advanced gastric adenocarcinoma

Table 1 No Correlation between EPR-1 protein expression and clinicopathological parameters

Clinico-pathological parameters	Cases	EPR-1 positive cases n (%)	P value
Age (yr)
<60	37	21 (56.8)
60	83	56 (67.5)	0.258
Sex
Male	72	43 (59.7)
Female	48	34 (70.8)	0.214
Tumor location
Upper 1/3	39	22 (56.4)
Middle 1/3	32	20 (62.5)
Lower 1/3	19	11 (57.9)
More than 2 locaitons	30	24 (80.0)	0.199
Differentation
Well	60	46 (76.7)
Poorly	60	31 (51.7)	0.004
Subtypes
Papillary	30	24 (80.0)
Tubular	30	22 (73.3)
Mucinous	30	13 (43.3)
Signet-ring cell	30	18 (60.0)	0.017
Invasion mucosa
No	66	40 (60.6)
Yes	54	37 (68.5)	0.369
Lymph node metastasis
No	70	43 (61.4)
Yes	50	34 (68.0)	0.459

Table 2 Different expression of EPR-1 between histological subtypes

Subtypes	Primary carcinoma	P value	Normal gastric mucosa	P value	Invasion node	P value	Lymph node metastasis	P value	Smooth muscle cell	P value
Papillary	24/30 (80.0)		14/30 (46.7)		14/17 (82.4)		11/13 (84.6)		17/30 (56.7)
Tubular	22/30 (73.3)		15/30 (50.0)		12/16 (75.0)		11/15 (73.3)		15/30 (50.0)
Mucinous	13/30 (43.3)		12/30 (40.0)		10/24 (41.7)		3/10 (30.0)		14/30 (46.7)
Signet-ring cell	18/30 (60.0)	0.017	15/30 (50.0)	0.849	11/28 (39.3)	0.007	9/12 (75.0)	0.033	18/30 (60.0)	0.72

Table 3 Different expression of EPR-1 in the highly-differentiated adenocarcinomas

Differentation	Primary gastric adenocar cinoma	Normal gastric mucosa cells	Invasion node adenocarcinoma	Lymph node metastasis	Smooth muscle cell	P value
Well	46/60 (76.7)	29/60 (48.3)	26/33 (78.8)	22/28 (78.6)	32/60 (53.3)	0.002
Poorly	31/60 (51.7)	27/60 (45.0)	21/52 (40.4)	12/15 (54.5)	32/60 (53.3)	0.594

Table 4 Significant expression difference of the AI and PI between EPR-1 positive and negative groups in primary adenocarcinomas

EPR-1	n	AI (%), mean ± SD	P value	PI (%), mean ± SD	P value
+	77	1.25±0.86		7.00 ± 3.28
-	43	1.00±0.80	0.024	8.53 ± 2.70	0.01

Table 5 Significant expression difference of the AI and PI be-tween EPR-1 positive and negative groups in lymph node metastasis

EPR-1	n	AI (%)	P value	PI (%)	P value
+	34	0.99 ± 0.58		7.65 ± 2.60
-	16	0.67 ± 0.24	0.01	9.44 ± 3.05	0.037