Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model

Table 1 Microvessel assessment of S-180 murine sarcoma tumors

Group	Microvessel density
No treatment	97.7 ± 15.2
rAAV-LacZ alone	105.2 ± 17.6
rAAV-LacZ plus etoposide	52.0 ± 9.4
rAAV-endostatin alone	19.3 ± 4.5
rAAV-endostatin plus etoposide	7.6 ± 1.5a

The microvessel density was measured with a light microscope in the tumor representative of the highest microvessel density at magnification × 200 (“hot spot”).

^aP < 0.05, rAAV-endostatin plus etoposide group against other groups.