Effect of O-4-ethoxyl-butyl-berbamine in combination with pegylated liposomal doxorubicin on advanced hepatoma in mice

Table 1 Tumor response and survival time of hepatoma-bear-ing mice after systemic treatment with Dox or PLD alone or in combination with EBB

Group	Tumor response1					Mean survivaltime (d)
	PD	NC	PR	CR	(PR+CR)%
Dox (n = 10)	10				0	29.7 ± 8.2a
Dox + EBB (n = 10)	5	2	3		30	70.1 ± 8.3ac
PLD (n = 10)	6	2	2		20	67.2 ± 9.1ac
PLD + EBB (n = 12)	2	1	6	3	75	89.2 ± 13.2aeg
Controls (n = 8)	8				0	18.2 ± 2.7

¹Tumor response was scored on d 0 and d 10 after start of treatment.

^aP < 0.05 compared with control group;

^cP < 0.05 compared with Dox alone;

^eP < 0.05 compared with Dox+EBB;

^gP < 0.05 compared with PLD alone.