Copyright
©The Author(s) 2004.
World J Gastroenterol. Nov 15, 2004; 10(22): 3278-3283
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3278
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3278
Table 1 Covariate distribution among study subjects and ORs for gastric cancer
Characteristics | No Cases (%) (n = 165) | No. Controls (%) (n = 295) | OR (95%CI) | |
Age (yr) | ||||
Mean (yr ± SD) | 59.36 ± 9.29a | 51.89 ± 10.24 | ||
Min. (yr) | 34.72 | 30.77 | ||
Max. (yr) | 81.95 | 78.21 | ||
Gender | ||||
Male (%) | 110 (66.67) | 190 (64.41) | ||
Female (%) | 55 (33.33) | 105 (35.59) | ||
Ratio | 2.00:1 | 1.81:1 | ||
Smoking habit | ||||
Never | 60 (36.36) | 119 (40.34) | 1.00 | |
Current | 44 (26.67) | 139 (47.12) | 0.26 (0.15–0.46)b | |
Past | 61 (36.97) | 37 (12.54) | 3.15 (1.77–5.61)b | |
Alcohol habits | ||||
Never | 97 (58.79) | 160 (54.24) | 1.00 | |
Current | 18 (10.91) | 91 (30.85) | 0.18 (0.10–0.35)b | |
Past | 50 (30.30) | 44 (14.92) | 1.80 (1.06–3.08) | |
Plasma H Pylori CagA antibody | ||||
Negative | 136 (82.42) | 107 (49.31) | 1.00 | |
Positive | 29 (17.58) | 110 (50.69) | 0.18 (0.11–0.31)b | |
iNOS genotyping | ||||
CC | 108 (75.52) | 189 (76.83) | 1.00 | |
CT | 33 (23.08) | 49 (19.92) | 1.15 (0.68–1.96) | |
TT | 2 (1.40) | 8 (3.25) | 0.42 (0.08–2.16) | |
CT + TT | 35 (24.48) | 57 (23.17) | 1.03 (0.59–1.79) |
Table 2 Interaction between C/T polymorphism and past cigarette smoking for the risk of gastric cancer
C/T polymo rphism | Past smoking | Total cases (n = 143) | Controls (n = 246) | OR1 | 95%CI | IGC (n = 93) | OR2 | 95%CI | GCC (n = 50) | OR3 | 95%CI |
CC | No | 67 | 162 | 1.00 | 46 | 1.00 | 21 | 1.00 | |||
CT + TT | No | 22 | 51 | 0.98 | 0.55-1.78 | 12 | 0.75 | 0.36-1.54 | 10 | 1.44 | 0.63-3.27 |
CC | Yes | 41 | 27 | 2.92 | 1.53-5.57 | 27 | 2.47 | 1.19-5.09 | 14 | 3.65 | 1.42-9.38 |
CT + TT | Yes | 13 | 6 | 3.62 | 1.23-10.64 | 8 | 3.06 | 0.91-10.35 | 5 | 4.63 | 1.15-18.58 |
Table 3 Interaction between C/T polymorphism and past alcohol drinking for the risk of gastric cancer
C/T polymorphism | Past alcohol drinking | Total cases (n = 143) | Controls (n = 246) | OR1 | 95%CI | IGC (n = 93) | OR2 | 95%CI | GCC (n = 50) | OR3 | 95%CI |
CC | No | 76 | 157 | 1.00 | 53 | 1.00 | 23 | 1.00 | |||
CT + TT | No | 24 | 51 | 0.83 | 0.46-1.50 | 13 | 0.62 | 0.30-1.28 | 11 | 1.22 | 0.55-2.70 |
CC | Yes | 32 | 32 | 1.34 | 0.72-2.52 | 20 | 1.36 | 0.67-2.75 | 12 | 1.27 | 0.50-3.19 |
CT + TT | Yes | 11 | 6 | 3.33 | 1.14-9.67 | 7 | 3.42 | 1.03-11.35 | 4 | 3.25 | 0.80-13.13 |
Table 4 Interaction between C/T polymorphism and H pylori CagA status for the risk of gastric cancer
C/T polymorphism | CagA antibody | Total cases (n = 143) | Controls (n = 178) | OR1 | 95%CI | IGC (n = 93) | OR2 | 95%CI | GCC (n = 50) | OR3 | 95%CI |
CC | No | 87 | 64 | 1.00 | 61 | 1.00 | 26 | 1.00 | |||
CT + TT | No | 28 | 19 | 2.53 | 1.29-4.98 | 17 | 2.19 | 1.01-4.76 | 11 | 3.52 | 1.44–8.61 |
CC | Yes | 21 | 73 | 0.45 | 0.25-0.81 | 12 | 0.34 | 0.17-0.70 | 9 | 0.76 | 0.33-1.73 |
CT + TT | Yes | 7 | 22 | 0.43 | 0.17-1.10 | 3 | 0.24 | 0.07-0.89 | 4 | 0.86 | 0.27-2.79 |
- Citation: Shen J, Wang RT, Wang LW, Xu YC, Wang XR. A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer. World J Gastroenterol 2004; 10(22): 3278-3283
- URL: https://www.wjgnet.com/1007-9327/full/v10/i22/3278.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i22.3278