Copyright
©The Author(s) 2004.
World J Gastroenterol. Nov 15, 2004; 10(22): 3274-3277
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3274
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3274
Table 1 Primer sequences of genes of interest
Region | Primer | Nucleotide sequence (5'→3') | PCR product (bp) | Reference |
26kDa | 26kDa-F | TGGCGTGTCTATTGACAGCGAGC | 298 | 9 |
26kDa-R | CCTGCTGGGCATACTTCACCAAG | |||
ureC | ureC-F | AAGCTTTTAGGGGTGTTAGGGGTTT | 294 | 10 |
ureC-R | AAGCTTACTTTCTAACACTAACGC | |||
cagA | cagA-F | AATACACCAACGCCTCCAAG | 400 | 11 |
cagA-R | TTGTTGCCGCTTTTGCTCTC | |||
vacA | vacA-F | GCTTCTCTTACCACCAATGC | 1160 | 12 |
vacA-R | TGTCAGGGTTGTTCACCATG | |||
m2-R | CATAACTAGCGCCTTGCAC | |||
iceA1 | iceA1-F | GTGTTTTTAACCAAAGTATC | 246 | 5 |
iceA1-R | CTATAGCCAGTCTCTTTGCA | 5 | ||
iceA2 | iceA2-F | GTTGGGTDTDTCACAATTTAT | 229/334 | 5 |
iceA2-R | TTGCCCTATTTTCTAGTAGGT | 5 | ||
babA2 | babA2-F | AATCCAAAAAGGAGAAAAAGTATGAAA | 831 | 4 |
babA2-R | TGTTAGTGATTTCGGTGTAGGACA | 4 |
Table 2 Relationship between H pylori status and disease states
Groups | No. of patients | No. of biopsies | No. of H pylori (+) | P |
PUD | 36 | 108 | 16 (44%) | - |
GERD | 50 | 150 | 15 (30%) | 0.169 |
NUD | 69 | 207 | 20 (29%) | 0.113 |
Table 3 Anatomical location of the 134 H pylori isolates and their virulence genes
Antrum (%) n = 43 | Body/Corpus (%) n = 47 | Cardia(%) n = 44 | |
Clinical Diagnosis | |||
PUD | 12 (33) | 15 (42) | 12 (33) |
GERD | 13 (26) | 15 (30) | 14 (28) |
NUD | 18 (25) | 17 (24) | 18 (26) |
Genotype | |||
26kDa | 43 (100) | 47 (100) | 44 (100) |
ureC | 43 (100) | 47 (100) | 44 (100) |
cagA | 35 (81) | 35 (74) | 33 (75) |
vacA | 37 (86) | 38 (81) | 35 (80) |
iceA1 | 25 (58) | 25 (53) | 26 (59) |
iceA2 | 10 (23) | 12 (26) | 9 (20) |
babA2 | 18 (42) | 20 (38) | 16 (36) |
Table 4 Distribution of virulence genes of 134 H pylori isolates from the same anatomical site of different patient groups
Isolates | 26kDa (%) | ureC (%) | cagA (%) | vacA (%) | iceA1(%) | iceA2(%) | babA2(%) | |
Antrum | ||||||||
PUD | 12 | 12 (100) | 12 (100) | 9 (75) | 10 (83) | 6 (50) | 4 (33) | 6 (50) |
GERD | 13 | 13 (100) | 13 (100) | 11 (85) | 11 (85) | 7 (54) | 2 (15) | 6 (46) |
NUD | 18 | 18 (100) | 18 (100) | 15 (83) | 16 (89) | 12 (67) | 4 (22) | 6 (33) |
Body/Corpus | ||||||||
PUD | 15 | 15 (100) | 15 (100) | 9 (60) | 10 (67) | 6 (40) | 5 (33) | 7 (47) |
GERD | 15 | 15 (100) | 15 (100) | 14 (93)1 | 14 (93) | 8 (53) | 3 (20) | 8 (53) |
NUD | 17 | 17 (100) | 17 (100) | 12 (71) | 14 (82) | 11 (65) | 4 (24) | 5 (29) |
Cardia | ||||||||
PUD | 12 | 12 (100) | 12 (100) | 9 (75) | 11 (92) | 5 (42) | 2 (17) | 3 (25) |
GERD | 14 | 14 (100) | 14 (100) | 12 (86) | 11 (79) | 8 (57) | 2 (14) | 7 (50) |
NUD | 18 | 18 (100) | 18 (100) | 12 (67) | 13 (72) | 13 (72) | 5 (28) | 7 (39) |
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Citation: Ho YW, Ho KY, Ascencio F, Ho B. Neither gastric topological distribution nor principle virulence genes of
Helicobacter pylori contributes to clinical outcomes. World J Gastroenterol 2004; 10(22): 3274-3277 - URL: https://www.wjgnet.com/1007-9327/full/v10/i22/3274.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i22.3274