Anti-tumor effect of pEgr-IFNγ gene-radiotherapy in B16 melanoma-bearing mice

Table 1 IFNγ mRNA level in B16 cells after irradiation with different doses

Dose (Gy)	Ratio of IFNγ mRNA level
0	0.819
2	0.972
5	1.347
10	1.950
20	2.144

Table 2 Tumor growth rate after gene-radiotherapy ( mean ± SD, n = 8)

Group	f (V/V0) on days after irradiation
	3 d	6 d	9 d	2 d	15 d
Control	1.23 ± 0.37	3.11 ± 1.5	12.29 ± 4.83	20.21 ± 7.62	22.80 ± 8.50
20 Gy	1.57 ± 0.19	2.34 ± 0.40	3.28 ± 0.68b	4.18 ± 0.66b	6.18 ± 1.40b
PcDNA3.1 + 20 Gy	1.86 ± 0.54	1.67 ± 0.40ad	2.26 ± 0.50bd	2.86 ± 0.58bd	5.19 ± 0.66b
PEgr-IFNγ	1.38 ± 0.23	1.76 ± 0.56b	2.61 ± 0.75b	5.23 ± 0.98b	8.03 ± 2.14b
PEgr-IFNγ + 20 Gy	0.48 ± 0.10bf	0.34 ± 0.11bf	0.38 ± 0.14bf	0.43 ± 0.11bf	0.35 ± 0.10bf

^aP < 0.05,

^bP < 0.001 vs control group;

^dP < 0.01,

^fP < 0.001 vs 20 Gy group.