A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium

Table 1 Body mass and colorectal length (mean ± SD)

Groups	A	B	C	D
Body mass (g)	24.09 ± 2.02a	25.9 ± 2.020a	31.00 ± 2.10	30.01 ± 1.02
Colon length (cm)	8.80 ± 0.98b	9.37 ± 0.90b	12.21 ± 0.94	12.66 ± 0.73

Significantly different from group D (

^aP < 0.05,

^bP < 0.01).

Table 2 Incidence of dysplasia/cancer and pathology score of UC (mean ± SD)

Group number	Mice	Number of dysplasiae/cancers			Pathology score of UC
		Proximal	Middle	Distal	Proximal	Middle	Distal
A	11	0.55 ± 0.82	0.73 ± 0.79	2.36 ± 1.12a	1.82 ± 0.40	1.72 ± 0.46	1.82 ± 0.40c
B	11	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	2.00 ± 0.63	1.82 ± 0.40	2.09 ± 0.54c
C	10	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
D	10	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0

^aP < 0.05, significantly different from proximal and middle portion of group A;

^cP < 0.05 significantly different from group D.