Ren ZG, Lin ZY, Xia JL, Ye SL, Ma ZC, Ye QH, Qin LX, Wu ZQ, Fan J, Tang ZY. Postoperative adjuvant arterial chemoembolization improves survival of hepatocellular carcinoma patients with risk factors for residual tumor: A retrospective control study. World J Gastroenterol 2004; 10(19): 2791-2794 [PMID: 15334671 DOI: 10.3748/wjg.v10.i19.2791]
Corresponding Author of This Article
Dr. Zhao-You Tang, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China. zytang@srcap.stc.sh.cn
Article-Type of This Article
Liver Cancer
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 1, 2004; 10(19): 2791-2794 Published online Oct 1, 2004. doi: 10.3748/wjg.v10.i19.2791
Table 1 Clinical and pathological characteristics in control and adjuvant TACE groups patients without risk factors for residual tumor
Characteristics
Control
Adjuvant TACE
P value
(n = 174)
group (n = 77)
Gender
Female
34
5
0.009
Male
140
72
Age (mean ± SD)
50.86 ± 11.61
49.35 ± 10.04
0.323
HBsAg
Positive
43
11
0.135
Negative
131
66
Cirrhosis
Absent
22
6
0.130
Mild
53
33
Severe
99
38
Child-pugh Class
A
165
77
0.134
B
5
0
AFP (mean ± SD, ug/L)
333.91 ± 529.92
406.04 ± 735.16
0.381
TNM classification
I
28
19
0.108
II
146
58
Table 2 Clinical and pathological characteristics in control and adjuvant TACE groups patients with risk factors for re-sidual tumor
Characteristics
Control
Adjuvant TACE group
P value
(n = 190)
(n = 108)
Gender
Female
33
12
0.147
Male
157
96
Age (mean ± SD)
51.50 ± 11.72
49.63 ± 10.07
0.105
HBsAg
Positive
47
27
0.588
Negative
143
81
Cirrhosis
Absent
41
24
0.563
Mild
69
45
Severe
80
39
Child-pugh Class
A
187
106
0.860
B
3
2
AFP (mean ± SD, μg/L)
501.39 ± 807.14
518.25 ± 707.99
0.856
TNM classification
II
113
66
0.926
IIIA
55
31
IVA
22
11
Table 3 Multivariate Cox proportional hazard analysis to evaluate independent variables in patients without risk fac-tors for residual tumor
Variables
B
Wald
Significance
HR
95%CI lower upper
Cirrhosis
0.689
14.443
0.000
1.991
1.396
2.841
Absent = 1
Mild = 2
Severe = 3
Tumor
0.235
6.019
0.014
1.264
1.048
1.525
diameter (cm)
Table 4 Multivariate Cox proportional hazard analysis to evaluate independent variables in patients with risk factors for residual tumor
Variables
B
Wald
Significance
HR
95% lower upper
AFP (μg/L)
0.212
5.333
0.021
1.236
1.033
1.480
< 20 = 1
21-400 = 2
> 400 = 3
Adjuvant TACE
-0.406
6.041
0.014
0.666
0.482
0.921
Without = 1
With = 2
Tumor diameter (cm)
0.076
16.327
0.000
1.079
1.040
1.119
Vascular invasion
0.245
7.691
0.006
1.278
1.075
1.520
Absent = 1
Present = 2
Citation: Ren ZG, Lin ZY, Xia JL, Ye SL, Ma ZC, Ye QH, Qin LX, Wu ZQ, Fan J, Tang ZY. Postoperative adjuvant arterial chemoembolization improves survival of hepatocellular carcinoma patients with risk factors for residual tumor: A retrospective control study. World J Gastroenterol 2004; 10(19): 2791-2794