Antigen epitope of Helicobacter pylori vacuolating cytotoxin A

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Aug 15, 2004 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

H Pylori

World J Gastroenterol. Aug 15, 2004; 10(16): 2340-2343
Published online Aug 15, 2004. doi: 10.3748/wjg.v10.i16.2340

Table 1 Site and amino acid sequences of predicted VacA epitopes

Site of amino acid	Amino acid sequences of predicted epitopes
35-46	AEEANKTPDKPD
61-66	PHKEYD
146-154	KDSADRTTR
297-317	GYKDKPKDKPSNTTQNNANNN
335-338	NSAQ
446-450	TDTKN
566-568	SGE
734-737	NNNR
746-748	TDD
766-768	DNY
799-806	TPTENGGN

Table 2 Inhibition of anti-LTB-VacA antibody on VacA toxin

Group	HeLa cells with vacuoles in total cells (%)	Change rate (%)
VacA toxin	49.52 ± 2.77	0
Anti-LTBantibody (Control)	47.51 ± 1.31	-4.05 ± 1.61
Anti-LTB-VacA1 antibody	34.47 ± 1.97	-30.41 ± 2.41^b
Anti-LTB-VacA2 antibody	39.52 ± 1.69	-20.20 ± 2.07^b
Anti-LTB-VacA3 antibody	42.51 ± 1.84	-14.17 ± 2.27^a

^aP < 0.05,

^bP < 0.01 vs control.

Citation: Liu XL, Li SQ, Liu CJ, Tao HX, Zhang ZS. Antigen epitope of Helicobacter pylori vacuolating cytotoxin A. World J Gastroenterol 2004; 10(16): 2340-2343
URL: https://www.wjgnet.com/1007-9327/full/v10/i16/2340.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i16.2340