Enhanced antitumor efficacy on hepatoma-bearing rats with adriamycin-loaded nanoparticles administered into hepatic artery

Table 1 Tumor volume (V) and tumor volume ratio (TVR) after treatment (mean ± SD)

Group	V (cm3)		TVR
	Before treatment	After treatment
NS	0.086 ± 0.049	2.521 ± 0.840	31.550 ± 7.975
FADR	0.083 ± 0.035	0.149 ± 0.072	1.883 ± 0.708b
ADR + NP	0.079 ± 0.036	0.161 ± 0.105	1.896 ± 0.565b
NADR	0.079 ± 0.033	0.087 ± 0.038	1.106 ± 0.275d

^bP < 0.01, vs NS;

^dP < 0.01, vs FADR, ADR + NP.

Table 2 Tumor necrosis degree after treatment

Grade	NS	FADR	ADR + NP	NADR
I	6	2	1	0
II	1	3	5	2
II	0	2	1	51

¹Complete necrosis in 2 cases.

Table 3 Mean survival time and increased life span (%ILS) after treatment (mean ± SD)

Group	Mean survival time (d)	%ILS
NS	18.88 ± 2.80	-
FADR	27.75 ± 6.34	46.98b
ADR + NP	26.13 ± 5.75	38.40b
NADR	39.50 ± 8.97	109.22a

^aP < 0.05, vs FADR, ADR + NP;

^bP < 0.01, vs NS.