Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population

Table 1 Primers designed for detection of CYP2C19*2

Genotype		Sequences
Wild-type	Forward	5’-AATTACAACCAGAGAGCTTGGC-3’
	Reverse	5’-GTAATTTGTTATGGGTTCCC-3’
Mutant	Forward	5’-AATTACAACCAGAGAGCTTGGC-3’
	Reverse	5’-GTAATTTGTTATGGGTTCCT-3’

Table 2 Primers designed for detection of CYP2C19*3

Genotype		Sequences
Wild-type	Forward	5’-TATTATTATCTGTTAACTAATATGA-3’
	Reverse	5’-AACTTGGCCTTACCTGGATC-3’
Mutant	Forward	5’-TATTATTATCTGTTAACTAATATGA-3’
	Reverse	5’-AACTTGGCCTTACCTGGATT-3’

Table 3 Frequencies of EMs and PMs in different cancer groups and control group

Group	Total	EMs (*1/*1, *1/*2 , *1/*3)		PMs (*2/*2,*2/*3)
	cases	Cases	%	Cases	%
Esophagus cancer	135	89	65.9	46	34.1
Stomach cancer	148	101	68.2	47	31.8
Lung cancer	212	139	65.6	73	34.4
Bladder cancer	112	107	95.5	5	4.5
Control	372	320	86.0	52	14.0

Esophagus cancer, χ² = 25.65, P < 0.005, OR = 3.18, 95%CI = 2.005-5.042; Stomach cancer, χ² = 21.70, P < 0.005, OR = 2.86, 95%CI = 1.820-4.501; Lung cancer, χ² = 33.58, P < 0.005, OR = 3.23, 95%CI = 1.503-6.906; Bladder cancer, χ² = 7.50, P < 0.01, OR = 0.288, 95%CI = 0.112-0.740.