Relationship between serum calcium and CA 19-9 levels in colorectal cancer

Table 1 Laboratory data of CRC patients (mean ± SE)

	CRC	Control	P	Normal value
Calcium (Ca)	2.26 ± 0.17	2.45 ± 0.09	0.0001	2.25-2.61 mmol/L
Corrected Ca	2.26 ± 0.14	2.37 ± 0.11	0.0001	2.25-2.61 mmol/L
Ionized calcium	1.07 ± 0.07	1.2 ± 0.05	0.0001	1.05-1.25 mmol/L
Phosphate	1.07 ± 0.13	1.2 ± 0.22	0.006	0.85-1.45 mmol/L
Albumin	39.5 ± 4.61	43.87 ± 4.37	0.0001	35-50 g/L
AFP	4.19 ± 2.85	3.34 ± 1.58	NS	0-15 ng/L
CEA	18.84 ± 69	1.79 ± 1.86	0.043	0-10 ng/L
CA 19-9	86.49 ± 406	10.20 ± 9.95	NS	0-37 ng/L
PTH	38.2 ± 16.8	41.5 ± 14.6	NS	10-65 pg/mL
25 (OH) vit. D	44.7 ± 73.8	46.84 ± 13.7	NS	20-60 ng/L
Age (yr)	65.6 ± 10.9	63.6 ± 8.2	NS	-

NS = no significant difference.

Table 2 Correlation between tumor marker levels and param-eters of calcium metabolism of CRC patients

	Ca	Corrected Ca	P	Ca2+	Albumin	PTH	25 (OH) vit. D
AFP	0.67	0.33	0.53	0.40	0.80	0.87	0.30
CEA	0.21	0.79	0.80	0.23	0.15	0.94	0.95
Ca19-9	0.57	0.57	0.63	0.007	0.10	0.74	0.94

Table 3 Laboratory parameters associated with different CaSR A986S genotypes (mean ± SE)

	AA	AS	P
Calcium	2.23 ± 0.16	2.31 ± 0.18	NS
Corrected Ca	2.24 ± 0.12	2.30 ± 0.14	NS
Phosphate	1.07 ± 0.13	1.08 ± 0.11	NS
Ionized calcium	1.07 ± 0.08	1.09 ± 0.07	NS
Albumin	39.61 ± 4.40	39.20 ± 5.30	NS
AFP	4.18 ± 2.96	4.29 ± 2.68	NS
CEA	9.2 ± 23.8	45 ± 125	NS
CA 19-9	68 ± 379	143 ± 492	NS
PTH	37.3 ± 14.2	41.2 ± 23.0	NS
25 (OH) vit. D	51 ± 85	27.3 ± 11.4	NS
Age (yr)	66.18 ± 10.96	64.8 ± 11.2	NS

NS = no significant difference.