Polymorphisms of interleukin-1B and interleukin-1 receptor antagonist genes in patients with chronic hepatitis B

Table 1 Comparison of IL-1B(-511) polymorphism between patients with chronic hepatitis B and controls

Group	n	Frequency of genotypes (%)			Frequency of alleles (%)
		CC	CT	TT	C	T
Patients	190	45 (23.7)	94 (49.5)	51 (26.8)	184 (48.4)	196 (51.6)
Controls	249	65 (26.1)	118 (47.4)	66 (26.5)	248 (49.8)	250 (50.2)

Patients vs controls, χ² = 0.35, P = 0.84; χ² = 0.16, P = 0.69.

Table 2 Comparison of IL-1RN intron 2 polymorphism between patients with chronic hepatitis B and controls

Group	n	Frequency of genotypes(%)				Frequency of alleles(%)
		1/1a	1/2b	2/2	1/4	1	2c	4
Patients	190	169 (88.9)	17 (9.0)	1 (0.5)	3 (1.6)	358 (94.2)	19 (5.0)	3 (0.8)
Controls	249	202 (81.1)	42 (16.9)	1 (0.4)	4 (1.6)	450 (90.4)	44 (8.8)	4 (0.8)

Patients vs controls,

^aχ² = 5.03, P = 0.025;

^bχ² = 5.81, P = 0.016;

^cχ² = 4.76, P = 0.029.

Table 3 Association between IL-1B, IL-RN genotypes and HBV copies in chronic hepatitis B patients

Subgroup	n	IL-1B genotype (%)				IL-1RN genotype (%)
		CCa	CT	TT	1/1	1/2	2/2	1/4
I	104	31 (29.8)	49 (47.1)	24 (23.1)	93 (89.4)	9 (8.7)	0	2 (1.9)
II	86	14 (16.3)	45 (52.3)	27 (31.4)	76 (88.3)	8 (9.3)	1 (1.2)	1 (1.2)

HBV-DNA ≤ 1×10³ copies/mL as I, HBV-DNA > 1×10³ copies/mL as II,

^asubgroup I vs subgroup II, χ² = 4.77, P = 0.029.