Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population

doi:10.3748/wjg.v10.i12.1810

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Jun 15, 2004 (publication date) through Dec 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 2004; 10(12): 1810-1814
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1810

Table 1 Main characteristics of study groups

Variable	Chronic HB	Self-limited HBV	P
	n = 207(%)	infection n = 148 (%)
Age (mean ± SD)	40.06 ± 14.55	37.75 ± 13.35	0.40
Male/Female	162/45	70/78	< 0.01
Marital status			0.01
Married	162 (78.26)	131 (88.51)
Unmarried	45 (21.74)	17 (11.49)
Education level			0.06
Lower than high school	13 (6.28)	18 (12.16)
High school	126 (60.87)	94 (63.51)
Above high school	68 (32.85)	36 (24.32)

Table 2 Genotype and allele frequencies in subjects with chronic HB and self-limited HBV infection

Group	n	Genotype (%)¹			Allele (%)²
Group	n	A/A	A/G	G/G	A	G
Chronic HB	207	0 (0.0)	4 (1.93)	203 (98.07)	4 (0.97)	410 (99.03)
Self-limited HBV infection	148	0 (0.0)	10 (6.76)	138 (93.24)	10 (3.38)	286 (96.62)

¹χ² = 5.30, P = 0.02,

²χ² = 5.20, P = 0.02.

Table 3 Association of behavior factors with risk of chronic HB

Characteristics	Chronic HB (%)	Self-limited HBV infection (%)	OR (95%CI)	P
Cigarette smoking			1.40 (0.87, 2.28)	0.14
Yes	74 (35.75)	42 (28.38)
No	133 (64.25)	106 (71.62)
Alcohol consumption			1.26 (0.78, 2.05)	0.32
Yes	69 (33.33)	42 (28.38)
No	138 (66.67)	106 (71.62)

Table 4 Multivariate logistic regression analysis for determinants of chronic HB

Variable	β	χ²	P	OR	95%CI
Intercept	-0.5076	7.2203	0.0072	—	—
Sex (Male = 1, Female = 0)	1.4088	35.1138	< 0.0001	4.091	2.567–6.519
-238G/A (GG = 1, GA = 0)	1.4183	5.1467	0.0233	4.132	1.212–14.085

Table 5 Case-control analysis for interaction between ciga-rette smoking and GG genotype

Cigarette	GG	Case¹	Control²	*OR (95%CI)*	P
smoking	genotype
-	-	3	6	1	—
-	+	130	100	2.60 (0.56-13.49)	0.19
+	-	1	4	0.50 (0.01-10.45)	1.00
+	+	73	38	3.84 (0.79-20.73)	0.07

¹Chronic HB patients,

²self-limited HBV infection individuals.

Table 6 Case-control analysis for interaction between alcohol consumption and GG genotype

Alcohol	GG	Case¹	Control²	*OR (95%CI)*	P
consumption	genotype
-	-	3	7	1	—
-	+	135	99	3.18 (0.72-15.96)	0.11
+	-	1	3	0.78 (0.02-18.21)	1.00
+	+	68	39	4.07 (0.08-21.25)	0.05

¹Chronic HB patients,

²self-limited HBV infection individuals.

Citation: Lu LP, Li XW, Liu Y, Sun GC, Wang XP, Zhu XL, Hu QY, Li H. Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population. World J Gastroenterol 2004; 10(12): 1810-1814
URL: https://www.wjgnet.com/1007-9327/full/v10/i12/1810.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i12.1810