Heme oxygenase-1 in cholecystokinin-octapeptipe attenuated injury of pulmonary artery smooth muscle cells induced by lipopolysaccharide and its signal transduction mechanism

Table 1 Change of MDA content in PASMCs (mean ± SD, n = 8)

Group	MDA content (nmol/mL )
Control	4.02 ± 2.18
LPS	23.44 ± 1.25a
LPS+CCK-8	14.66 ± 1.66e
CCK-8	3.00 ± 2.18
LPS+ZnPP	34.97 ± 1.54ae
LPS+CCK-8+ZnPP	29.68 ± 2.18ec

^aP < 0.05 vs Control group,

^cP < 0.05 vs LPS+CCK-8 group,

^eP < 0.05 vs LPS group.

Table 2 Changes of HO-1 and c-fos protein expression by immumocytochemistry in PASMCs (mean ± SD, n = 6)

Group	Area (%)		(A)
	HO-1	c-fos	HO-1	c-fos
Control	2.10 ± 0.01	1.18 ± 0.02	0.02 ± 0.009	0.03 ± 0.021
LPS	20.18 ± 0.08a	18.95 ± 0.07a	0.19 ± 0.07a	0.20 ± 0.01a
LPS+CCK-8	28.91 ± 0.36c	29.87 ± 0.33c	0.47 ± 0.04c	0.45 ± 0.02c
CCK-8	21.27 ± 1.05	20.16 ± 0.98	0.31 ± 0.02	0.33 ± 0.01

^aP < 0.05 vs Control group,

^cP < 0.05 vs LPS group.