Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.83
Revised: August 2, 1998
Accepted: August 21, 1998
Published online: October 15, 1998
AIM: To compare the long-term therapeutic effects of cisapride and domperidone Ddt on functional dyspepsia (FD).
METHODS: Randomly choosing 40 patients treated with cisapride and 32 patients treated with domperidone, of uhom the symptoms of FD completely disappeared after the 4 wk treatment, respectively. And the symptoms of FD completely disappeared. In the cisapride group, 21 were men, 19 were women, aged 19-72 years, average age 38 years, their disease course ranged from 1 mo to 13 years, average 27 mo. Among them, 19 with dysmotility-like dyspepsia, 4 with gastroesophageal reflux-like dyspepsia, 10 with ulcer-like dyspepsia, 7 with complex dyspepsia. In the domperidone group 17 were men, 15 were women, age 19-74 years, average age 39 years, their disease course ranged from 1 mo to 14 years, average couse 26 mo. Among them, 16 with dysmotility-like dyspepsia, 3 with gastroesophageal reflux-like dyspepsia, 9 with ulcer-like dyspepsia, 4 with complex dyspepsia. All of the patients were treated either with cisapride (5 mg, twice per day) or domperidone (10 mg, twice per day) and main tained the treatment for 12 mo. During this period, observation was made of the recurrence of satiety, epigastric pain, epigastric distention, early satiety, nausea, vomiting anorexia, belch which appeared after they had meals, and as well as side effects. The patients’ symptoms were compared and analysed.
RESULTS: After 12 mo’s treatment, epigastric pain recurred in 1 patient, respectively; in the cisapride group. Epigastric distension, early satiety. The recurrence rate was 7.5%. In the domperidone group, early satiety recurred in 3 patients, heartburn in 1, epigastric pain in 2, epigastric distention in 4. The recurrence rate was 31.2%, and the symptoms were more severe ( P < 0.01). Side effects: In the cisapride group, loose stool occurred in 1 patient, stool frequency increased in 1. The occurrence rate was 5.0%. In the domp eridone group, loctorrhea, abnormal menstruation, agitation, drowsiness, loose s tool and palpitation occurred in one patient, respectively. The occurrence rate was 18.7%.
CONCLUSION: Ddt cisapride has better therapeutic effects than domperidone, and it can significantly decrease the recurrence of functional dyspepsia.
- Citation: Liang ZG, Quan HB. Analysis of long-term therapeutic effects of cisapride and domperidone on functional dyspepsia. World J Gastroenterol 1998; 4(Suppl2): 83-83
- URL: https://www.wjgnet.com/1007-9327/full/v4/iSuppl2/83.htm
- DOI: https://dx.doi.org/10.3748/wjg.v4.iSuppl2.83
E- Editor: Li RF