Sinusoidal endotheliitis as a histological parameter for diagnosing acute liver allograft rejection

Figure 2 Spectrum of sinusoidal pathology. A: lymphocytes in sinusoidal spaces, with adhesion to endothelium but without lifting of endothelial cells; B: Grade 1 sinusoidal endotheliitis with subendothelial linear lymphocytic infiltration; C: Grade 2 sinusoidal endotheliitis with subendothelial lymphocyte clusters and partially disrupted endothelium; D: Grade 3 sinusoidal endotheliitis with endothelial damage, fresh hemorrhage, lymphohistiocytic infiltration and adjacent liver cell necrosis; E: Grade 3 sinusoidal endotheliitis with collapsed liver cell plates on reticulin staining; F: Grade 3 sinusoidal endotheliitis with collagen deposition on Masson trichrome staining (hematoxylin-eosin staining, magnification × 400).