Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.614
Peer-review started: August 12, 2016
First decision: September 5, 2016
Revised: September 16, 2016
Accepted: October 19, 2016
Article in press: October 19, 2016
Published online: January 28, 2017
Processing time: 160 Days and 7.2 Hours
To determine the frequency of bleeding source detection in patients with obscure gastrointestinal bleeding (OGIB) who underwent double balloon enteroscopy (DBE) after pre-procedure imaging [multiphase computed tomography enterography (MPCTE), video capsule endoscopy (VCE), or both] and assess the impact of imaging on DBE diagnostic yield.
Retrospective cohort study using a prospectively maintained database of all adult patients presenting with OGIB who underwent DBE from September 1st, 2002 to June 30th, 2013 at a single tertiary center.
Four hundred and ninety five patients (52% females; median age 68 years) underwent DBE for OGIB. AVCE and/or MPCTE performed within 1 year prior to DBE (in 441 patients) increased the diagnostic yield of DBE (67.1% with preceding imaging vs 59.5% without). Using DBE as the gold standard, VCE and MPCTE had a diagnostic yield of 72.7% and 32.5% respectively. There were no increased odds of finding a bleeding site at DBE compared to VCE (OR = 1.3, P = 0.150). There were increased odds of finding a bleeding site at DBE compared to MPCTE (OR = 5.9, P < 0.001). In inpatients with overt OGIB, diagnostic yield of DBE was not affected by preceding imaging.
DBE is a safe and well-tolerated procedure for the diagnosis and treatment of OGIB, with a diagnostic yield that may be increased after obtaining a preceding VCE or MPCTE. However, inpatients with active ongoing bleeding may benefit from proceeding directly to antegrade DBE.
Core tip: The yield of double balloon enteroscopy (DBE) without preceding video capsule endoscopy (VCE) or multiphase computed tomography enterography (MPCTE) was 59.4%, and with preceding imaging was 67.5%. Overall diagnostic yield of antegrade DBE is superior to CTE and equivalent to VCE in the evaluation of obscure gastrointestinal bleeding. The diagnostic yields of DBE for inpatients vs outpatients were similar but the highest sensitivity of VCE using DBE as gold standard was in inpatients (84.9%). The incremental diagnostic yield of DBE of all patients with negative preceding VCE and MPCTE was 66% (35/53 patients). An appropriate strategy might be antegrade DBE in inpatients with evidence of ongoing bleeding if DBE is available.
- Citation: Law R, Varayil JE, WongKeeSong LM, Fidler J, Fletcher JG, Barlow J, Alexander J, Rajan E, Hansel S, Becker B, Larson JJ, Enders FT, Bruining DH, Coelho-Prabhu N. Assessment of multi-modality evaluations of obscure gastrointestinal bleeding. World J Gastroenterol 2017; 23(4): 614-621
- URL: https://www.wjgnet.com/1007-9327/full/v23/i4/614.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i4.614
Obscure gastrointestinal bleeding (OGIB) is defined as bleeding from the gastrointestinal (GI) tract that persists or recurs without an obvious etiology after negative upper endoscopy and colonoscopy[1,2]. OGIB is further categorized into “obscure overt” or “obscure occult” bleeding based on presence or absence of evident bleeding and accounts for approximately 5% of all GI bleeding[3]. Though lesions may be missed in the esophagus, stomach, and colon, the etiology of OGIB is secondary to small bowel pathology in up to 75% of cases[4-6] leading some experts to recommend that this term be replaced by the term ‘small bowel bleeding’[7]. The evaluation of OGIB frequently requires significant utilization of resources and results in patient frustration due to lack of definitive findings and clinical improvement in many cases[8].
The current American Society of Gastrointestinal Endoscopy guidelines recommend a variety of diagnostic options when evaluating OGIB, with slight differences between the “overt” and “occult” GI bleeding algorithms[9]. At many referral centers, multiphase computed tomography enterography (MPCTE) and/or video capsule endoscopy (VCE) are performed after a negative routine endoscopic exam but prior to double balloon enteroscopy (DBE) as these diagnostic studies are less invasive and may direct DBE-guided therapies[10,11]. MPCTE allows for evaluation of dynamic changes in abnormal enhancement patterns and compares findings across phases in 2-dimensional and 3-dimensional images[12]. Images are evaluated in arterial, enteric and delayed phases allowing for evaluation of ongoing or recent bleeding. In contrast, VCE requires ingestion of a small pill-size camera that provides endoluminal photographs of the entire GI tract for evaluation of small bowel mucosal lesions. These technologies are generally considered complimentary as each can provide different but vital information in the evaluation of OGIB. Though generally performed before DBE, there is a paucity of data regarding how often these tests alter subsequent diagnostic evaluation or treatment.
In this study, we aimed to determine the frequency of bleeding source detection in patients with OGIB who underwent DBE (antegrade/retrograde) after pre-procedure imaging (i.e. MPCTE, VCE, or both) and to assess the impact of imaging on DBE diagnostic yield. We also aimed to assess the agreement between findings of the pre-procedure imaging and the DBE itself.
A retrospective cohort study was conducted following the approval of the Institutional Review Board of Mayo Clinic-Rochester (IRB No. 13-002000 and No. 14-009997). Medical records were reviewed of all adult patients presenting with OGIB who underwent a DBE (antegrade/retrograde) from September 1st, 2002 to June 30th, 2013 using a prospectively maintained DBE database. Patients who underwent DBE for indications other than OGIB (i.e. enteral feeding tube placement, failed colonoscopy, evaluation for hereditary polyposis syndromes, small bowel mass, strictures, etc.) were excluded. The electronic medical record was utilized to obtain demographic, endoscopic, radiologic, and clinical outcomes data. At our institution, single balloon enteroscopy is not utilized for assessment of OGIB, and hence this procedure was not included in our study.
Demographic features including age at the time of DBE procedure, gender, and gastrointestinal surgeries prior to DBE were recorded. The total number of blood transfusions up to 30 d prior to the date of DBE procedure and the use of anticoagulant/antiplatelet agents at the time of procedure were collected. Details of VCE and MPCTE performed prior to the DBE were also collected. Only VCE and MPCTE performed within 1 year prior to the DBE procedure were included. All VCE were performed using Pillcam or Pillcam2 (Given Imaging, Yoqneam, Israel). When VCE was performed prior to DBE the date of the procedure, positive and negative findings, and time from VCE to DBE were noted. Positive VCE findings were categorized as (1) arteriovenous malformation (AVM); (2) red spot; (3) frank blood; (4) polyp; (5) ulcer; or (6) other[13]. Similarly, when MPCTE was performed prior to DBE, positive or negative findings and time from MPCTE to DBE were recorded. Positive MPCTE findings were categorized as (1) vascular malformations; (2) blood; (3) polyp/tumor; (4) ulcer; and (5) other[14,15]. Cross-sectional imaging findings were abstracted from the final radiologic report.
DBE procedural details included the approach (antegrade vs retrograde), type of obscure bleeding (overt vs occult), and hospital admission status (inpatient vs outpatient). The OGIB was defined as “overt” when the clinician’s note reported it to be overt or when there was clinically-evident bleeding including melena or hematochezia reported in the medical records. OGIB was defined as “occult” when the clinician’s review reported it to be occult, or when iron deficiency anemia or positive stool testing for blood loss were the sole indication for DBE. We documented whether total enteroscopy was achieved, defined as complete evaluation of the small bowel using either a single approach or combined antegrade-retrograde approach. Findings from DBE were classified into (1) vascular lesions (angioectasias/AVMs, Dieulafoy’s lesion, or ectopic varices); (2) mucosal lesions [erythema, erosions, ulcers, inflammation]; or (3) tumor/polyp[16]. If none of the above findings were seen, then the DBE was reported as negative. Therapies performed including argon plasma coagulation (APC), biopsy, hemostatic clip placement, bipolar cauterization, polypectomy and stricture dilation were also recorded. Adverse events including bleeding within 7 d of the procedure, perforation, pancreatitis and re-bleeding within 1 year of the procedure were recorded. Any repeat DBE performed within 1 year of the index DBE was documented.
The statistical methods of this study were reviewed by Joseph Larson and Felicity Enders, PhD from the Mayo Clinic Division of Health Sciences Reserch. Continuous measures were summarized using medians and ranges while categorical measures were summarized using counts and percentages. Differences among two groups were assessed using the Kruskall-Wallis test and Chi-square or Fisher’s exact test for continuous or categorical measures, respectively.
To evaluate the predictive ability of VCE and MPCTE to identify bleeding sites, DBE was treated as the gold standard and the sensitivity, specificity, diagnosis yield, and accuracy were calculated among patients with VCE and MPCTE within one year of DBE. Ninety-five percent confidence intervals for each of these measures were also determined. This analysis was repeated among the following subgroups; antegrade and retrograde approach, inpatient and outpatient procedure, overt and occult bleeding.
Because the same patients underwent VCE or MPCTE and DBE, to assess the findings from the procedures, matched logistic regression performed with the finding treated as the outcome and the DBE test treated as the predictor. Odds ratios and 95% confident intervals along with P values are presented for these tests.
All analyses used an significance level of 5% and were performed using the SAS (v9.3, SAS Institute Inc., Cary, NC, United States).
During the study period, 495 patients [51.5% females; median age 68.2 (range: 18.1-95.4) years] underwent DBE for OGIB. Overt OGIB was reported in 253 (51.1%) patients, and occult OGIB was reported in 242 (48.9%) patients. The procedure was performed in an outpatient setting in 381 (77.0%) patients and in an inpatient setting in 114 (23.0%) patients. The type of DBE approach was antegrade in 331 (75.1%) patients and retrograde in 110 (24.9%) patients. Total enteroscopy was achieved in a bidirectional manner in 19 (4.3%). Additional demographic data including DBE cases with surgically-altered anatomy and the use anticoagulant/antiplatelet agents is noted in Table 1.
| DBE negative | DBE positive | Total | P value | |
| (n = 164) | (n = 331) | (n = 495) | ||
| Age at DBE, median (range) | 65.0 (18.1-95.4) | 69.5 (18.3-91.8) | 68.2 (18.1-95.4) | 0.0051 |
| Gender | 0.1042 | |||
| Male | 71 (43.3) | 169 (51.1) | 240 (48.5) | |
| Female | 93 (56.7) | 162 (48.9) | 255 (51.5) | |
| Altered anatomy | 0.7362 | |||
| None | 125 (76.2) | 249 (75.2) | 374 (75.6) | |
| Roux-en-Y | 13 (7.9) | 21 (6.3) | 34 (6.9) | |
| Billroth/Ileo-colonic/IPAA | 7 (4.3) | 21 (6.3) | 28 (5.7) | |
| Other | 19 (11.6) | 40 (12.1) | 59 (11.9) | |
| On warfarin | 19 (11.6) | 36 (10.9) | 55 (11.1) | 0.8132 |
| On clopidogrel | 7 (4.3) | 20 (6.0) | 27 (5.5) | 0.4132 |
| On ASA 325 | 49 (29.9) | 118 (35.6) | 167 (33.7) | 0.2012 |
| VCE performed within 1 yr prior to DBE | 47 (29.4) | 130 (40.9) | 177 (36.9) | |
| MPCTE performed within 1 yr prior to DBE | 31 (19.4) | 53 (16.7) | 84 (17.5) | |
| VCE and MPCTE performed within 1 yr prior to DBE | 67 (41.9) | 113 (35.5) | 180 (37.8) | |
| DBE performed without VCE and MPCTE done | 15 (9.4) | 22 (6.9) | 37 (7.7) | |
| Type of OGIB | 0.7282 | |||
| Overt | 82 (50.0) | 171 (51.7) | 253 (51.1) | |
| Occult | 82 (50.0) | 160 (48.3) | 242 (48.9) | |
| Type of approach of DBE | < 0.0012 | |||
| Anterograde | 103 (62.8) | 268 (81.0) | 371 (74.9) | |
| Retrograde | 61 (37.2) | 63 (19.0) | 124 (25.1) | |
| Total enteroscopy done | 9 (5.5) | 15 (4.5) | 24 (4.8) | 0.6412 |
| Procedure location | 0.3932 | |||
| Inpatient | 34 (20.7) | 80 (24.2) | 114 (23.0) | |
| Outpatient | 130 (79.3) | 251 (75.8) | 381 (77.0) |
Of the 495 patients, 458 patients had had VCE and/or MPCTE performed prior to DBE (441 patients within 1 year prior to DBE). Of the 441 patients, 296 had a positive DBE finding (yield of 67.1%). The findings noted on DBE in these patients are outlined in Table 2. The remaining 37 patients underwent a DBE without a preceding VCE or MPCTE. Of these 37 patients, 22 had a positive finding (yield of 59.5%, P = 0.36).
| DBE negative | DBE positive | Total | |
| (n = 145) | (n = 296) | (n = 441) | |
| DBE findings | |||
| Angioectasia/arterio venous malformation | 0 (0.0) | 212 (71.6) | 212 (48.1) |
| Dieulafoy lesion | 0 | 8 (2.7) | 8 (1.8) |
| Varix | 0 | 3 (1.0) | 3 (0.7) |
| Evidence of Crohn’s disease | 0 | 5 (1.7) | 5 (1.1) |
| Erythema | 0 | 19 (6.4) | 19 (4.3) |
| Erosion | 0 | 31 (10.1) | 31 (6.8) |
| Ulcer | 0 | 56 (18.9) | 56 (12.7) |
| Polyp identified | 0 | 50 (16.9) | 50 (11.3) |
| Other findings | 40 (27.6) | 64 (21.6) | 104 (23.6) |
| Therapy and complications | |||
| Any therapy done? | 4 (2.8) | 296 (100) | 300 (68.0) |
| Epinephrine injection | 1 (0.7) | 2 (0.7) | 3 (0.7) |
| Biopsy | 3 (2.1) | 89 (30.1) | 92 (20.9 ) |
| Clipping | 0 | 67 (22.6) | 67 (15.2) |
| Argon plasma coagulation | 0 | 213 (72.0) | 213 (48.3) |
| Bipolar cauterization | 0 | 10 (3.4) | 10 (2.3) |
| Early re-bleeding (< 24 h) | 0 | 7 (2.4) | 7 (1.6) |
| Late re-bleeding (24 h-1 yr) | 4 (2.8) | 14 (4.7) | 18 (4.1) |
| Pancreatitis | 0 | 1 (0.3) | 1 (0.2) |
Among the 441 patients with VCE and/or MPCTE prior to DBE, therapeutic or diagnostic applications were performed in 300 (68.0%) patients including APC in 213 (48.3%) patients, biopsy in 92 (20.9%) patients, hemostatic clip placement in 67 (15.2%) patients, and bipolar cauterization in 10 (2.3%) patients. Early rebleeding (< 24 h from the time of procedure) was reported in 7 (2.4%) patients when the DBE was positive. Late rebleeding (24 h - 1 year from the time of index DBE) was reported in 14 (4.7%) patients when DBE findings were positive and 4 (2.8%) patients when DBE findings were negative (Table 2). A single patient developed pancreatitis and there were no perforations as complications.
Among 337 patients who had a VCE performed within the year preceding DBE, a bleeding site was identified at VCE in 171 (73.4%) patients when the DBE was positive and in 74 (71.2%) patients when the DBE was negative (P = 0.692). The median number of days between VCE and DBE was not significantly different when the DBE was positive (42; range: 0-356) or negative (35; range: 0-351) (P = 0.924) (Table 3). Using DBE as the gold standard, VCE had a sensitivity of 73.4% (95%CI: 67.7%-79.1%), specificity of 28.8% (95%CI: 20.1%-37.6%), and diagnostic yield of 72.7% (95%CI: 67.9%-77.5%) (Table 4). Among the patients with negative DBE, the commonest VCE findings were AVM (26.0%), blood (22.1%) and ulcer (16.3%).
| Capsule endoscopy | Computed tomography enterography | |||||||
| DBE negative | DBE positive | Total | P value | DBE negative | DBE positive | Total | P value | |
| (n = 104) | (n = 233) | (n = 337) | (n = 95) | (n = 157) | (n = 252) | |||
| Capsule endoscopy positive | 74 (71.2) | 171 (73.4) | 245 (72.7) | 0.6922 | ||||
| MPCTE positive | 27 (28.4) | 55 (35.0) | 82 (32.5) | 0.3322 | ||||
| Days from VCE to DBE, median (range) | 42 (0-356) | 35 (0-351) | 37 (0-356) | 0.9241 | ||||
| Days from MPCTE to DBE, median (range) | 19 (0-338) | 29 (0-351) | 23.5 (0-351) | 0.1621 | ||||
| VCE and DBE within 30 d of each other | 41 (39.4) | 105 (45.1) | 146 (43.3) | 0.3442 | ||||
| MPCTE and DBE within 30 d of each other | 59 (62.1) | 84 (53.5) | 143 (56.7) | 0.1922 | ||||
| Arterio-venous malformation | 27 (26.0) | 94 (40.3) | 121 (35.9) | 0.0142 | ||||
| Vascular lesion | 13 (48.1) | 32 (58.2) | 45 (54.9) | 0.1082 | ||||
| Blood | 23 (22.1) | 51 (21.9) | 74 (22.0) | 0.9992 | ||||
| Red spot | 13 (12.5) | 18 (7.7) | 31 (9.2) | 0.2202 | ||||
| Polyp | 4 (3.8) | 12 (5.2) | 16 (4.7) | 0.7842 | ||||
| Ulcer | 17 (16.3) | 20 (8.6) | 37 (11.0) | 0.0402 | 2 (7.4) | 1 (1.8) | 3 (3.7) | |
| Other | 2 (7.4) | 0 (0.0) | 2 (2.4) | |||||
| Comparison test | Statistic | Count summary | % | 95%CI | |
| Lower limit (%) | Upper limit (%) | ||||
| VCE | Total, n | 337 | |||
| Sensitivity | 171/233 | 73.4 | 67.7 | 79.1 | |
| Specificity | 30/104 | 28.8 | 20.1 | 37.6 | |
| DX yield | 245/337 | 72.7 | 67.9 | 77.5 | |
| Accuracy | 201/337 | 59.6 | 54.4 | 64.9 | |
| MPCTE | Total, n | 252 | |||
| Sensitivity | 55/157 | 35.0 | 27.6 | 42.5 | |
| Specificity | 68/95 | 71.6 | 62.5 | 80.6 | |
| DX yield | 82/252 | 32.5 | 26.8 | 38.3 | |
| Accuracy | 123/252 | 48.8 | 42.6 | 55.0 | |
In 252 patients who had MPCTE in the year preceding DBE, a bleeding site was identified in 55 (35.0%) patients when the DBE was positive and in 27 (28.4%) patients when the DBE was negative. The median number of days between MPCTE to DBE was not significantly different when the DBE was positive (19.0; range: 0-338) or negative (29; range: 0-351) (P = 0.162) (Table 3). Using DBE as the gold standard, MPCTE had a sensitivity of 35.0% (95%CI: 27.6%-42.5%), specificity of 71.6% (95%CI: 62.5%-80.6%), and diagnostic yield of 32.5% (95%CI: 26.8%-38.3%) (Table 4). Among patients with negative DBE, the most common MPCTE findings were vascular lesions (48.1%), blood (33.3%), and ulcer (7.4%).
Of 53 patients who had preceding negative test(s), 35 (66.0%) had a positive DBE. Of these with positive DBE, 28 (80.0%) were antegrade DBE, 16 (45.7%) were for overt bleeding, and only 4 (11.4%) were in inpatients. AVMs were the commonest finding, found in 23 (65.7%) patients and treated with APC.
Of the 37 patients who went straight to DBE without preceding CE or MPCTE, the DBE was done antegrade in 26 (70.3%) patients, in 13 (35.1%) inpatients, and for overt bleeding in 26 (70.3%) patients. The commonest findings at DBE were AVM in 17 (45.9%) and ulcer in 8 (21.6%).
In order to compare findings on DBE to VCE and MPCTE, matched odds ratios were examined. There were no increased odds of finding a bleeding site at DBE compared to VCE (OR = 1.3, 95%CI: 0.9-1.7, P = 0.150). There were increased odds of finding a bleeding site at DBE compared to MPCTE (OR = 5.9, 95%CI: 3.5-9.7, P < 0.001).
When comparing by DBE approach, VCE had a diagnostic yield of 75.6% (95%CI: 70.3%-80.9%) with an antegrade approach; and a diagnostic yield of 63.9% (95%CI: 53.5%-74.2%) with a retrograde approach. MPCTE had a diagnostic yield of 31.6% (95%CI: 24.9%-38.2% with the antegrade approach and diagnostic yield of 35.4% (95%CI: 23.8%-47.0%) with a retrograde approach (Supplementary Table 1).
When comparing by procedure setting, VCE had a diagnostic yield of 76.7% (95%CI: 67.0%-86.4%) in the inpatient setting and a diagnostic yield of 71.6% (95%CI: 66.2%-77.0%) in the outpatient setting. With the inpatient setting, MPCTE had a diagnostic yield of 40.8% (95%CI: 27.1%-54.6%) and a diagnostic yield of 30.5% (95%CI: 24.2%-36.9%) with the outpatient setting (Supplementary Table 2). Thus, in the inpatient setting, VCE had higher diagnostic yield than MPCTE.
When comparing overt to occult bleeding, VCE had a diagnostic yield of 72.9% (95%CI: 66.3%-79.6%) for overt bleeds and a diagnostic yield of 72.5% (95%CI: 65.7%-79.2%) for occult bleeds. With overt bleeds, MPCTE had a diagnostic yield of 34.4% (95%CI: 26.0%-42.9%) and a diagnostic yield of 30.8% (95%CI: 22.8%-38.7%) with occult bleeds (Supplementary Table 3).
Small bowel bleeding is the commonest cause of OGIB, seen in 75% of cases[17]. Identifying the site of bleeding and its therapy remain challenging due to this anatomic location. DBE is an effective way to address these challenges but is costly and not readily available at all centers. Our study aimed to look at the diagnostic yield of DBE and of preceding VCE and MPCTE. This would allow us to analyze the need for imaging prior to DBE. In our large single center cohort of 495 patients with OGIB, the yield of DBE without preceding VCE or MPCTE was 59.4%, and with preceding imaging was 67.5%. Thus, although the diagnostic yield of DBE is higher when pre-DBE imaging is positive, a source lesion is frequently identified when pre-DBE imaging is negative or not performed.
Using direct visualization by DBE as the gold standard, VCE had a diagnostic yield of 72.7% but a relatively low specificity of 28.8%. This is similar to prior studies[18]. The commonest findings at VCE with negative DBE were AVMs and blood; it is possible that these abnormalities had subsided by the time of the DBE since the time interval between the tests in our study could be up to 1 year[11,19]. This would be characteristic of AVMs which often bleed intermittently, and could artificially increase the apparent false positive rate.
A preceding MPCTE was done in fewer patients compared to VCE and had a lower diagnostic yield of 32.5%. However, the specificity was higher at 71.6%, also similar to previous studies[14,20,21]. The vascular lesions seen in nearly half the patients with positive MPCTE and negative DBE were likely deep in the bowel wall and hence not seen endoscopically.
Antegrade DBEs overall had higher diagnostic yields than retrograde DBEs (72.51% vs 50.91%, P < 0.001. This has been shown in one other smaller series[22]. Thus, the overall diagnostic yield of antegrade DBE is superior to CTE and roughly equivalent to VCE in the evaluation of OGIB. This is an important finding because it suggests that almost all patients should undergo antegrade DBE before retrograde, unless otherwise dictated by abnormal MPCTE suggesting ileal tumors or polyps.
The diagnostic yields of DBE for inpatients vs outpatients were similar in our data but the highest sensitivity of VCE using DBE as gold standard was in inpatients (84.9%). This group also showed the highest specificity (45.0%). Interestingly the incremental diagnostic yield of DBE of all patients with negative preceding VCE and MPCTE was 66% (35/53 patients). Thus, this raises the question of whether an appropriate strategy might be to directly proceed to antegrade DBE in inpatients with evidence of ongoing bleeding if DBE is available. This is also reflected by the matched odds ratios comparing VCE and MPCTE to DBE where there were no increased odds of finding a bleeding site at DBE compared to VCE and increased odds at DBE compared to MPCTE. In our data, none of the tests had a significantly higher yield in patients with overt bleeding compared to occult bleeding, which is unlike prior studies[23-25]
In conclusion, our data suggest that DBE is a generally safe and well tolerated procedure for the diagnosis and treatment of OGIB, with a diagnostic yield that may be increased after obtaining a preceding VCE or MPCTE. However, inpatients with active ongoing bleeding may benefit from proceeding directly to antegrade DBE, which has the benefits of improved diagnostic yield in these patients, ability to intervene therapeutically, and avoidance of an additional diagnostic test. A prospective evaluation and cost-effectiveness analysis of this clinical algorithm would be warranted.
The etiology of obscure gastrointestinal bleeding (OGIB) is secondary to small bowel pathology in up to 75% of cases. The authors sought to determine the frequency of bleeding source detection in patients with OGIB who underwent double balloon enteroscopy (DBE) after pre-procedure imaging (multiphase computed tomography enterography, video capsule endoscopy, or both) and assess the impact of imaging on DBE diagnostic yield.
Diagnostic yields of DBE, computed tomography enterography and video capsule enteroscopy in obscure gastrointestinal (GI) bleeding.
This is the one of the largest cohort of patients with occult GI bleeding undergoing DBE for occult GI bleeding. A large proportion of patients also had preceding imaging, allowing for comparison of the various techniques.
Inpatients with active ongoing bleeding may benefit from proceeding directly to antegrade DBE without preceding testing, which has the benefits of improved diagnostic yield in these patients, ability to intervene therapeutically, and avoidance of an additional diagnostic test.
Obscure GI bleeding - GI bleeding where etiology is not in the esophagus, stomach, or colon.
Even though the theme has been studied for years allover the world, it is still necessary to update and clarify the best approach to a challenging clinical entity such as OGIB. This study is uptodate and follows the most recent guidelines and studies.
Manuscript source: Unsolicited manuscript
Specialty type: Gastroenterology and hepatology
Country of origin: United States
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P- Reviewer: de’ Angelis GL, Lakatos PL, Sharma P S- Editor: Yu J L- Editor: A E- Editor: Liu WX
| 1. | Gralnek IM. Obscure-overt gastrointestinal bleeding. Gastroenterology. 2005;128:1424-1430. [PubMed] [Cited in This Article: ] |
| 2. | Raju GS, Gerson L, Das A, Lewis B. American Gastroenterological Association (AGA) Institute medical position statement on obscure gastrointestinal bleeding. Gastroenterology. 2007;133:1694-1696. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 159] [Cited by in F6Publishing: 150] [Article Influence: 8.8] [Reference Citation Analysis (0)] |
| 3. | Szold A, Katz LB, Lewis BS. Surgical approach to occult gastrointestinal bleeding. Am J Surg. 1992;163:90-92; discussion 92-93. [PubMed] [Cited in This Article: ] |
| 4. | Chong J, Tagle M, Barkin JS, Reiner DK. Small bowel push-type fiberoptic enteroscopy for patients with occult gastrointestinal bleeding or suspected small bowel pathology. Am J Gastroenterol. 1994;89:2143-2146. [PubMed] [Cited in This Article: ] |
| 5. | Davies GR, Benson MJ, Gertner DJ, Van Someren RM, Rampton DS, Swain CP. Diagnostic and therapeutic push type enteroscopy in clinical use. Gut. 1995;37:346-352. [PubMed] [Cited in This Article: ] |
| 6. | Pennazio M, Arrigoni A, Risio M, Spandre M, Rossini FP. Clinical evaluation of push-type enteroscopy. Endoscopy. 1995;27:164-170. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 90] [Cited by in F6Publishing: 92] [Article Influence: 3.2] [Reference Citation Analysis (0)] |
| 7. | Gerson LB, Fidler JL, Cave DR, Leighton JA. ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding. Am J Gastroenterol. 2015;110:1265-1287; quiz 1288. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 368] [Cited by in F6Publishing: 401] [Article Influence: 44.6] [Reference Citation Analysis (1)] |
| 8. | Gerson LB. Small bowel endoscopy: cost-effectiveness of the different approaches. Best Pract Res Clin Gastroenterol. 2012;26:325-335. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 14] [Cited by in F6Publishing: 14] [Article Influence: 1.2] [Reference Citation Analysis (0)] |
| 9. | Fisher L, Lee Krinsky M, Anderson MA, Appalaneni V, Banerjee S, Ben-Menachem T, Cash BD, Decker GA, Fanelli RD, Friis C. The role of endoscopy in the management of obscure GI bleeding. Gastrointest Endosc. 2010;72:471-479. [PubMed] [DOI] [Cited in This Article: ] [Cited by in F6Publishing: 1] [Reference Citation Analysis (0)] |
| 10. | Singh V, Alexander JA. The evaluation and management of obscure and occult gastrointestinal bleeding. Abdom Imaging. 2009;34:311-319. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 25] [Cited by in F6Publishing: 26] [Article Influence: 1.7] [Reference Citation Analysis (0)] |
| 11. | Singh A, Marshall C, Chaudhuri B, Okoli C, Foley A, Person SD, Bhattacharya K, Cave DR. Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study. Gastrointest Endosc. 2013;77:761-766. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 87] [Cited by in F6Publishing: 82] [Article Influence: 7.5] [Reference Citation Analysis (0)] |
| 12. | Huprich JE, Fletcher JG, Fidler JL, Alexander JA, Guimarães LS, Siddiki HA, McCollough CH. Prospective blinded comparison of wireless capsule endoscopy and multiphase CT enterography in obscure gastrointestinal bleeding. Radiology. 2011;260:744-751. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 125] [Cited by in F6Publishing: 128] [Article Influence: 9.8] [Reference Citation Analysis (0)] |
| 13. | Liao Z, Gao R, Xu C, Li ZS. Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review. Gastrointest Endosc. 2010;71:280-286. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 472] [Cited by in F6Publishing: 431] [Article Influence: 30.8] [Reference Citation Analysis (0)] |
| 14. | Huprich JE, Barlow JM, Hansel SL, Alexander JA, Fidler JL. Multiphase CT enterography evaluation of small-bowel vascular lesions. AJR Am J Roentgenol. 2013;201:65-72. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 59] [Cited by in F6Publishing: 47] [Article Influence: 4.3] [Reference Citation Analysis (0)] |
| 15. | Jeon SR, Jin-Oh K, Gun KH, Hee LT, Jun-Hyung C, Ju PE, Seop LD, Jung KW, Min KB, Young CJ. Is there a difference between capsule endoscopy and computed tomography as a first-line study in obscure gastrointestinal bleeding? Turk J Gastroenterol. 2014;25:257-263. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 10] [Cited by in F6Publishing: 11] [Article Influence: 1.2] [Reference Citation Analysis (0)] |
| 16. | Chu Y, Wu S, Qian Y, Wang Q, Li J, Tang Y, Bai T, Wang L. Complimentary Imaging Modalities for Investigating Obscure Gastrointestinal Bleeding: Capsule Endoscopy, Double-Balloon Enteroscopy, and Computed Tomographic Enterography. Gastroenterol Res Pract. 2016;2016:8367519. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 14] [Cited by in F6Publishing: 20] [Article Influence: 2.2] [Reference Citation Analysis (0)] |
| 17. | Pasha SF, Leighton JA, Das A, Harrison ME, Decker GA, Fleischer DE, Sharma VK. Double-balloon enteroscopy and capsule endoscopy have comparable diagnostic yield in small-bowel disease: a meta-analysis. Clin Gastroenterol Hepatol. 2008;6:671-676. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 270] [Cited by in F6Publishing: 255] [Article Influence: 15.9] [Reference Citation Analysis (0)] |
| 18. | Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, Fort JG. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol. 2005;3:133-141. [PubMed] [Cited in This Article: ] |
| 19. | Yamada A, Watabe H, Kobayashi Y, Yamaji Y, Yoshida H, Koike K. Timing of capsule endoscopy influences the diagnosis and outcome in obscure-overt gastrointestinal bleeding. Hepatogastroenterology. 2012;59:676-679. [PubMed] [DOI] [Cited in This Article: ] [Cited by in F6Publishing: 23] [Reference Citation Analysis (0)] |
| 20. | Lee SS, Oh TS, Kim HJ, Chung JW, Park SH, Kim AY, Ha HK. Obscure gastrointestinal bleeding: diagnostic performance of multidetector CT enterography. Radiology. 2011;259:739-748. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 62] [Cited by in F6Publishing: 63] [Article Influence: 4.8] [Reference Citation Analysis (0)] |
| 21. | Sodhi JS, Zargar SA, Rashid W, Shaheen F, Singh M, Javid G, Ali S, Khan BA, Yattoo GN, Shah A. 64-section multiphase CT enterography as a diagnostic tool in the evaluation of obscure gastrointestinal bleeding. Indian J Gastroenterol. 2012;31:61-68. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 9] [Cited by in F6Publishing: 10] [Article Influence: 0.8] [Reference Citation Analysis (0)] |
| 22. | Sanaka MR, Navaneethan U, Kosuru B, Yerneni H, Lopez R, Vargo JJ. Antegrade is more effective than retrograde enteroscopy for evaluation and management of suspected small-bowel disease. Clin Gastroenterol Hepatol. 2012;10:910-916. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 35] [Cited by in F6Publishing: 34] [Article Influence: 2.8] [Reference Citation Analysis (0)] |
| 23. | Agrawal JR, Travis AC, Mortele KJ, Silverman SG, Maurer R, Reddy SI, Saltzman JR. Diagnostic yield of dual-phase computed tomography enterography in patients with obscure gastrointestinal bleeding and a non-diagnostic capsule endoscopy. J Gastroenterol Hepatol. 2012;27:751-759. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 35] [Cited by in F6Publishing: 33] [Article Influence: 2.8] [Reference Citation Analysis (0)] |
| 24. | Aniwan S, Viriyautsahakul V, Rerknimitr R, Angsuwatcharakon P, Kongkam P, Treeprasertsuk S, Kullavanijaya P. Urgent double balloon endoscopy provides higher yields than non-urgent double balloon endoscopy in overt obscure gastrointestinal bleeding. Endosc Int Open. 2014;2:E90-E95. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 32] [Cited by in F6Publishing: 35] [Article Influence: 3.5] [Reference Citation Analysis (0)] |
| 25. | Bresci G, Parisi G, Bertoni M, Tumino E, Capria A. The role of video capsule endoscopy for evaluating obscure gastrointestinal bleeding: usefulness of early use. J Gastroenterol. 2005;40:256-259. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 105] [Cited by in F6Publishing: 118] [Article Influence: 6.2] [Reference Citation Analysis (0)] |