Understanding the role of PIN1 in hepatocellular carcinoma

Figure 1 Structure of peptidyl-prolyl-isomerase PIN1 protein. Ribbon diagrams of (A) PIN1 (NCBI Structure No. 1NMV), (B) WW binding domain (NCBI Structure No. 1I8H), and (C) PPIase catalytic domain (NCBI Structure No. 1NMW) were drawn with the Swiss-Pdb Viewer[11,15,115,116]. α-helices and β-strands are denoted by coils and arrows, respectively. Residues Ser(S)¹⁶, Tyr(Y)²³ and Trp(W)³⁴ in the WW domain are critical for phospho-protein binding, while residues Lys(K)⁶³, Ser(S)⁶⁷, Arg(R)^68/69 and Cys(C)¹¹³ contribute to the PPIase activity. Adapted from thesis: Identification and characterization of PIN1 binding partners, HKU 2010.