Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression

Figure 3 Presumed roles of Pim-3 in pancreatic carcinogenesis. Pim-3 expression is regulated at transcriptional and post-transcriptional levels by transcription factors (such as Ets-1) and post-translational controllers (such as translationally controlled tumor protein), respectively. Pim-3 kinase activation contributes to pancreatic carcinogenesis by inducing cell survival, cell cycle progression, gene transcription, protein synthesis in tumor cells, and angiogenesis.