Simple animal model of Helicobacter pylori infection

Figure 1 Illustration of Helicobacter pylori rat inoculation. A: Male Sprague-Dawley rats 120-150 g; B: Pretreatment with streptomycin (5 mg/kg) for three consecutive days; C and D: H. pylori in microaerophilic condition: 5% O₂, 50% CO₂, 37 °C; E and F: H. pylori 10⁸-10¹⁰ CFU/mL, suspended in saline; G: Gavage, 1 mL/rat twice daily at an interval of 4 h, for three consecutive days. H. pylori: Helicobacter pylori.