Liver transplantation for nonalcoholic fatty liver disease: New challenges and new opportunities

Figure 1 Development of post-transplant nonalcoholic fatty liver disease depends on a combination of host and graft factors. Schematic representation of potential mechanistic pathways that lead to development of post-transplant nonalcoholic fatty liver disease including genetic background, metabolic syndrome, insulin resistance and the effects of immunosuppressive medications. Recurrent of de novo nonalcoholic steatohepatitis (NASH) may eventually lead to the development of graft cirrhosis and the need for re-transplantation. IL28B: Interleukin 28B; PNPLA3: Patatin-like phospholipase domain-containing protein 3; DM: Diabetes mellitus; HTN: Hypertension.