Diagnostic and therapeutic implications of the association between ferritin level and severity of nonalcoholic fatty liver disease

Figure 1 Proposed mechanisms explaining iron induced liver damage associated with steatosis and hepatic iron overload in hepatocytes (brown), macrophages (grey), and hepatic stellate cells (yellow). Cp: Ceruloplasmin; Fe-Tf: Ferric-transferrin; Fp-1: Ferroportin-1; HCC: Hepatocellular carcinoma; HFE: Hemochromatosis gene; HSCs: Hepatic stellate cells; MDA: Malonyl-dialdehyde; ROS: Reactive oxygen species; SOD2: Mn superoxide dismutase; Tf-R: Transferrin receptor. Modified from Dongiovanni et al[19].