INTRODUCTION
Acute appendicitis is the most common surgical emergency which may be complicated by the development of an appendiceal mass in 2%-10% of cases[1]. This mass results from a walled-off appendiceal perforation and represents a wide pathological spectrum ranging from an inflammatory mass that consists of the inflamed appendix, some adjacent viscera and the greater omentum (a phlegmon) to a periappendiceal abscess[2]. Ultrasonography has been advocated as the diagnostic modality of choice, revealing the diagnosis in 70% of cases, however, contrast-enhanced computerized tomography (CT) scanning is far superior[1]. The standard treatment which was introduced by Ochsner in 1901 advocating a conservative regimen (nil by mouth, intravenous antibiotics, bed rest and watchful observation) has proved popular over the years and has been shown to be safe and effective[1]. It allows the acute inflammatory process to subside in more than 80% of cases before interval appendicectomy (I.A) is performed some 8-12 wk later. However, some management issues of appendiceal mass such as the need for I.A after successful conservative treatment, and emergency appendicectomy for a ‘hot’ appendix mass have recently surfaced with no general consensus or agreement on the appropriate line of management.
THE CONTROVERSY OVER INTERVAL APPENDICECTOMY
A recent questionnaire study of 67 surgeons in the Mid Trent region of England showed no agreed consensus on the management of appendiceal mass[3]. One of the controversial management issues is the need for I.A after successful conservative treatment. A survey of 663 surgeons in North America revealed that I.A is routinely performed by 86% of the surveyed surgeons[4]. The most cited reason is the risk of recurrent appendicitis which is reported to occur in 21%-37% of cases[4,5]. Another questionnaire survey of 90 consultant general surgeons in England (response rate: 78%) revealed that 53% of surgeons perform I.A routinely some 6-8 wk after resolution of the mass; mainly because of concerns about symptom recurrence[6]. However, the study from Mid Trent region, U.K showed that more than 75% of surveyed surgeons do so[3]. Moreover, the specialist registrars are less likely to offer patients routine I.A after successful conservative management than their consultants (P < 0.05)[3] which may reflect a change in the attitude of younger surgeons towards I.A.
The argument of recurrent appendicitis has been questioned as it occurs in less than 20% of cases and the risk becomes minimal after the first 2 years of the initial episode[3,7]. Hence, more than 80% of patients with appendiceal mass can be spared the morbidity of a surgical intervention that has questionable validity. Moreover, a recent large retrospective population-based cohort study of 1012 patients treated initially with conservative therapy showed that only 39 (5%) patients developed recurrent symptoms after a median follow-up of 4 years with male sex having a slight influence on recurrence[4]. Hence, it may be concluded that I.A after initial successful conservative treatment is not justified[4].
THE ARGUMENTS AGAINST I.A
A prospective non-randomized study of 48 I.A specimens, showed 37 (77%) appendices to have a patent lumen, while only 11 (23%) showed fibrosis and obliteration of appendicular lumen and symptom recurrence approaching 40%[5]. This fact has led some authors to advocate routine I.A. However, this means subjecting many patients to unnecessary I.A which necessitates a second admission and is not entirely free of complications; the reported complication rate of I.A is 12%-23%[1,8,9]. It seems that the driving force behind I.A after successful conservative treatment is the fear of symptom recurrence. Many other studies, however, have confirmed a low recurrence which is highest during the first 2 years of the initial inflammation[3,7]. A recent prospective randomized controlled trial (RCT) showed that patients treated conservatively without I.A had the shortest hospital stay and duration of work-days lost, and only 10% of patients developed recurrent appendicitis during a median follow-up period of more than 33.5 mo[10]. This overwhelming evidence from a well conducted RCT and the fact that the histological examination of 30% of the I.A specimens were found to be normal with no evidence of previous inflammation[1] argues strongly against routine I.A after the successful conservative treatment of an appendix mass.
Moreover, 83% of patients presenting with appendix mass did not require any intervention over a mean follow-up of 15.5 mo[11]. Therefore, I.A should not be the rule in every patient presenting with appendiceal mass. Karaca et al[12] demonstrated complete disappearance of the mass on repeat ultrasonography and normal appendix on barium enema in 10 out of 11 children with appendiceal mass who were treated conservatively with triple antibiotics for a week. None of these patients developed recurrent appendicitis during the follow-up period of 1-7 years, confirming that conservative treatment is feasible with no need for I.A[12]. However, a week of intravenous triple antibiotics in hospital [12,13] and repeated ultrasonography[12] is certainly not cost-effective. This cost needs to be compared with the cost of emergency laparoscopic appendicectomy (LA) for appendix mass. In term of costs, routine I.A is indeed not cost-effective as it involves another admission and an operation which is not free of complications; it increases the cost per patient by 38% compared with a more selective approach (follow-up and appendectomy only if recurrence occurs)[14].
Furthermore, only very few (20%) patients benefit from prevention of recurrent symptoms if I.A is performed after 6-12 wk and the complication rates for appendicectomy performed before or after recurrence of symptoms were equal at 10%[15].
HIDDEN PATHOLOGY
If I.A is not performed after successful conservative treatment, the fear of missing hidden pathologies such as cecal cancer, Crohn’s disease and ileo-cecal tuberculosis masquerading as an appendiceal mass becomes an important issue. In a recent retrospective review of 106 patients, 17 (10.3%) patients had their diagnosis changed during follow-up; 5 patients (3%) were found to have colon cancer[15]. It is therefore essential to perform some follow up investigations to exclude the presence of such hidden pathologies. It is advocated to perform barium enema or colonoscopy after the acute episode has subsided in patients who have been treated conservatively[15], especially if aged more than 40 years[7,12]. However, there is no general consensus as to the right time to perform such an investigation. Timing is important as incompletely resolved appendix mass may mimic cecal carcinoma on barium enema and may give false positive results. A CT scan or CT colonography augmented -when indicated- by colonoscopy is far superior in excluding cecal pathology. It is believed that such investigations can be performed safely 4-6 wk after the acute episode[16].
IS I.A “SOMETHING” OF THE PAST?
Is I.A ‘something’ of the past? The short answer is no, as delayed appendicectomy is needed for patients with recurrent symptoms and those with a patent or chronically inflamed appendix[17]. The problem of how to determine the patency of the appendix and chronicity of the inflammation still remains in patients presenting with appendiceal mass who have settled on conservative treatment[16]. This may be done by performing barium enema on all patients treated conservatively and only those with patent appendices may be offered LA. However, this may prove impractical, costly and may increase the workload of any radiology department. Contrast-enhanced CT scanning is another modality that may help in this regard as it may strongly suggest the presence of underlying neoplasm in the majority of patients with secondary appendicitis[18].
EMERGENCY SURGERY FOR APPENDIX MASS IN THE LAPAROSCOPIC ERA
Fear of the increased risk of intraabdominal abscesses[19] after performing LA in complicated appendicitis has recently been dismissed[20]. The successful adoption of laparoscopic I.A after successful conservative treatment is reported without perioperative morbidity[21,22] and the percentage of I.As which are performed laparoscopically has increased in recent years from 30% to 85%[22]. The operating time and complication rates did not differ from those of open I.A, but the hospital stay was much shorter in favor of the interval laparoscopic method[20,22-25].
Is there a role for LA in the emergency intervention for appendiceal mass? The answer is yes. Senapati et al[21] reported experience with emergency LA in patients with appendiceal mass in comparison with LA for non-mass-forming appendicitis. It was found that early emergency LA for appendiceal mass is feasible and safe; moreover, its operative time and hospital stay are comparable to those of LA performed for non-mass forming appendicitis]. However, the proper timing for emergency surgery needs further substantiation.
Another major advantage of emergency surgery is that it obviates the need for a second hospital admission, avoids misdiagnoses and promptly deals with any unexpected ileo-cecal pathology that masquerades as an appendiceal mass. Furthermore, LA can be offered safely and successfully in the interval setting after successful conservative treatment for those with recurrent symptoms [20,22-25].
THE NEED FOR RCTS
The majority of -if not all- studies on I.A after conservative treatment of appendiceal mass are retrospective. The need for prospective randomized controlled multi-institutional trials is essential to scientifically compare emergency surgery for appendiceal mass with conservative management without I.A[26]. Such trials are needed to establish the safety of emergency open vs laparoscopic appendicectomy for appendix mass and to establish the safety of omitting I.A in those treated conservatively with successful outcomes. Such studies should look into various cost issues and the possible differences -if any- in the management of appendiceal masses in various age groups (pediatric vs adults) and different sexes (males vs females)[26]. The question of “golden hours” for emergency LA for ‘hot’ appendix masses -similar to that identified for emergency laparoscopic cholecystectomy for acute cholecystitis- needs to be answered. The possibility of increased infertility in females with appendiceal masses treated conservatively should also be studied to determine if emergency surgery is more beneficial in affected females in order to make a stronger argument for emergency management, at least, in females.
CONCLUSION
Based on the above, it seems that I.A can be safely omitted after exclusion of other ilo-cecal pathologies. This avoids a second hospital admission and a surgical procedure which is associated with a 10%-20% complication rate. I.A will still be reserved for patients with recurrent symptoms and can be performed safely by laparoscopic means. Emergency laparoscopic appendicectomy is emerging as a new safe treatment modality for the appendiceal mass, and may prove to be more cost-effective than conservative treatment even without I.A as it is associated with a much shorter hospital stay and obviates the need for long intravenous antibiotic therapy. It further obviates the need for I.A; the centre of controversy. If emergency LA becomes the standard of care, I.A will certainly become ‘something’ of the past.
Peer reviewer: Giuseppe Kito Fusai, MS, FRCS, Consultant Surgeon and Clinical Lead Hepato-pancreato-biliary Surgery, Honorary Senior Lecturer University College London Medical School HPB and Liver Transplant Unit, Royal Free Hospital, Pond Street, London NW32QG, United Kingdom
S- Editor Sun H L- Editor Webster JR E- Editor Ma WH