Osna NA. An annual topic highlight: Alcohol and liver, 2011. World J Gastroenterol 2011; 17(20): 2455-2455 [PMID: 21633649 DOI: 10.3748/wjg.v17.i20.2455]
Corresponding Author of This Article
Natalia A Osna, MD, PhD, Liver Study Unit, Research Service (151), VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, United States. nosna@unmc.edu
Article-Type of This Article
Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Natalia A Osna, Liver Study Unit, Research Service (151), VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, United States
ORCID number: $[AuthorORCIDs]
Author contributions: Osna NA wrote this editorial.
Correspondence to: Natalia A Osna, MD, PhD, Liver Study Unit, Research Service (151), VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, United States. nosna@unmc.edu
Telephone: +1-402-9953576 Fax: +1-402-4490604
Received: January 29, 2011 Revised: March 1, 2011 Accepted: March 8, 2011 Published online: May 28, 2011
Abstract
An annual topic highlight: Alcohol and Liver, 2011, covers the important and new aspects of pathogenesis of alcoholic liver diseases (ALD). It includes broad topics ranging from the exacerbation of ALD by infectious (viral) agents (hepatitis C virus and human immunodeficiency virus) to the influence of alcohol on liver fibrogenesis, lipid rafts, autophagy and other aspects. This issue is recommended for both basic scientists and clinicians who are involved in alcoholic liver research.
This annual topic highlight is the fourth issue of reviews devoted to alcoholic liver diseases (ALD) pathogenesis and treatment. It is one of the most respectful annual series of reviews in alcohol research, and now it has an established audience as well as the contributing authors, who are the leading specialists in alcohol studies, including experts from National Institute on Alcohol Abuse and Alcoholism. Here, we cover new aspects of alcohol research that were not addressed in our previous issues. Because alcohol exposure induces epigenetic changes in liver cells, two articles of this Topic Highlight[1,2] focused on the epigenetic regulation in ALD. Another two articles[3,4] addressed the mechanisms of pro-fibrotic changes in ALD. Several articles[5-7] summarized the available animal models for studying HCV infection based on “second-hit” effects of infections in ALD progression. In addition, other important aspects of ALD pathobiology, such as the role of lipid rafts, microRNAs, MSGT1, hepatic stellate cells and innate immunity and the proteasome inhibitor for ALD treatment are included in this issue[8-12].
This Topic Highlight provides an overview of the most modern literature/approaches in the alcohol research and is strongly recommended for gastroenterologists, hepatologists and scientists who work in this field.
Moghe A, Joshi-Barve S, Ghare S, Gobejishvili L, Kirpich I, McClain CJ, Barve S. Histone modifications and alcohol-induced liver disease: Are altered nutrients the missing link?World J Gastroenterol. 2011;17:2465-2472.
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Aziz-Seible RS, Casey CA. Fibronectin: Functional character and role in alcoholic liver disease.World J Gastroenterol. 2011;17:2482-2499.
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Szabo G, Zakhari S. Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients.World J Gastroenterol. 2011;17:2500-2506.
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Osna NA, Thomes PG, Donohue TM Jr. Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis.World J Gastroenterol. 2011;17:2507-2514.
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Mercer DF. Animal models for studying hepatitis C and alcohol effects on liver.World J Gastroenterol. 2011;17:2515-2519.
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Bardag-Gorce F. Proteasome inhibitor treatment in alcoholic liver disease.World J Gastroenterol. 2011;17:2558-2562.
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