Letters To The Editor Open Access
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World J Gastroenterol. Aug 7, 2006; 12(29): 4767-4767
Published online Aug 7, 2006. doi: 10.3748/wjg.v12.i29.4767
TREM-1 expression during major abdominal surgery: Comment on the Gonzalez-Roldan et al paper
Sebastien Gibot, Service de Réanimation Médicale, Hôpital Central, and Laboratoire de Physiologie Expérimentale (Groupe Choc), Faculté de Médecine, Nancy, France
Correspondence to: Dr Sebastien Gibot, Service de Réanimation Médicale, 29 bld du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy 54035, France. s.gibot@chu-nancy.fr
Telephone: +33-3-83852970 Fax: +33-3-83858511
Received: February 7, 2006
Revised: February 8, 2006
Accepted: February 28, 2006
Published online: August 7, 2006

Abstract



TO THE EDITOR

I read with a great interest the paper by Gonzalez-Roldan et al[1]. The authors reported on the pattern expression of TREM-1 during sepsis and major abdominal surgery as compared to healthy controls and concluded that TREM-1 expression increased on the surface of monocytes after surgery. Several points deserve consideration. First, no data related to TREM-1 expression on neutrophils is provided. Second, of the 7 surgical patients, only 4 had both pre- and post-surgery cytometry analysis. Among these 4 patients, 2 displayed a decrease of TREM-1 expression after surgery. Therefore, it seems quite hazardous, based on these data, to conclude that TREM-1 increases after major uncomplicated surgery, reflecting a systemic inflammatory response.

The other question that arose from this study is related to the determination of the TREM-1 splice variant (svTREM-1). First, it is still unknown whether this variant is translated or not[2]. Anyway, the soluble form of TREM-1 is not believed to be related to this variant[3]. The authors observed an increase of the svTREM-1 mRNA after surgery or during sepsis. By using the described primers, one could also expect to see a PCR product corresponding to the natural form of TREM-1[3]. Unfortunately, such a product is not reported. Finally, it is rather disappointing not to see any measurement of plasma sTREM-1 in these patients in order to better characterise the “inflammatory” patients and the septic ones[4].

Footnotes

S- Editor Wang J E- Editor Bi L

References
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2.  Gingras MC, Lapillonne H, Margolin JF. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol Immunol. 2002;38:817-824.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 100]  [Cited by in F6Publishing: 107]  [Article Influence: 4.9]  [Reference Citation Analysis (0)]
3.  Gibot S, Kolopp-Sarda MN, Béné MC, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med. 2004;200:1419-1426.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 265]  [Cited by in F6Publishing: 289]  [Article Influence: 14.5]  [Reference Citation Analysis (0)]
4.  Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004;350:451-458.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 411]  [Cited by in F6Publishing: 405]  [Article Influence: 20.3]  [Reference Citation Analysis (0)]