Effect of caffeic acid phenethyl ester on proliferation and apoptosis of hepatic stellate cells in vitro

Figure 1 The hepatic stellate cells stained with toluidine after cultured for 10 d after isolation (× 66).

Figure 2 Effects of CAPE on ³H-TdR and ³H-proline uptake by HSCs. ^aP < 0.05; ^bP < 0.01 vs groups without CAPE treatment.

Figure 3  Effect of CAPE on type I and III procollagen gene expression. ^aP < 0.05 vs the group without CAPE treatment.

Figure 4 Apoptotic HSCs detected by TUNEL without (A) or with 40 μmol/L CAPE treatment (B).

Figure 5 Effects of CAPE on HSC apoptosis. ^aP < 0.05; ^bP < 0.01 vs the groups without CAPE treatment; ^cP < 0.01 vs the group with 40 μmol/L CAPE treated for 12 h.