Mechanisms for regulation of gastrin and somatostatin release from isolated rat stomach during gastric distention

Figure 1 Release of gastrin and somatostatin from perfused rat stomachs in control (n = 8) and during gastric distention with 5 mL (n = 8), 10 mL (n = 15) and 15 mL (n = 8) saline (mean ± SE)

Figure 2 Integrated release of gastrin, somatostatin from per-fused rat stomachs in control (n = 8) and during gastric distention with 5 mL (n = 8), 10 mL (n = 15) and 15 mL (n = 8) saline. (mean ± SE) ^aP < 0.05 vs 10 mL distention in control

Figure 3 Integrated release of gastrin and somatostatin from perfused rat stomachs during gastric distention with 10 mL in control (n = 15) and in presence of tetrodotoxin (TTX, 10^-6 M; n = 10), atropine (Atro, 10^-7 M; n = 10), somatostatin-antagonist (SA, 10^-6 M; n = 15) and a combination of somatostatin-antagonist and atropine (n = 15), (mean ± SE). ^aP < 0.05 vs 10 mL distention in control.

Figure 4 Effect of somatostatin-14 (10^-6 M) on gastrin release from perfused rat stomachs prestimulated by GRP (10^-8 M) in control (n = 11) and during perfusion with somatostatin-antago-nist (10^-6 M; n = 9). (mean ± SE)