Effects of histone acetylation and DNA methylation on p21WAF1 regulation

Figure 1 There are more CpG island at the domain near by the transcription start site in the promoter of p21^WAF1 gene.

Figure 2 The nucleotide sequence of the p21^WAF1 promoter from -149 through +1. There are the E1 and E2 binding sites.

Figure 3 Butyrate, TSA, TPX and Apicidin inhibits HDAC enzyme activity, and HAT from p300/CBP, P/CAF and GCN5 resulting in histone hyperacetylat ion of H3 or H4 associated p21^WAF1 gene, and induces transcriptional activation of the p21^WAF1 gene.