Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers

Figure 1 Chiral high performance liquid chromatogram of racemic propafenone in rat liver microsomal incubates after 30 min incubation. A: BNF pre-treated B: without incubation. Peaks 1, 2: Diastereomers of S(+)-propafenone and R(-)-propafenone; Peaks 3, 4: Diastereomers of metabolite (N-desalkylpropafenone)

Figure 3 Concentration-time curves for S(+)- and R(-)-propafenone metabolism in rat hepatic microsomes. A: Control; B: BNF; C: DEX.

Figure 3 Dixon plot for S(+)-propafenone (Left) and R(-)-propafenone (Right) wit nimodipine as inhibitor at three concentration. Ki for S (+)-and R(-)-PPF was 15.4, 8.mg•L¯¹, respectively. Each data point represents the mean of duplicate determinations.