Lenvatinib, sintilimab combined interventional treatment vs bevacizumab, sintilimab combined interventional treatment for intermediate-advanced unresectable hepatocellular carcinoma

Figure 1 Flowchart for patient selection. HCC: Hepatocellular carcinoma; BeSiIT: Bevacizumab plus sintilimab plus interventional treatment; LeSiIT: Lenvatinib plus sintilimab plus interventional treatment; PSM: Propensity score matching.

Figure 2 Kaplan-Meier curves between the lenvatinib plus sintilimab plus interventional treatment and bevacizumab plus sintilimab plus interventional treatment groups. A: Kaplan-Meier curves based on propensity score matching (PFS) before propensity score matching (PSM); B: Kaplan-Meier curves based on overall survival (OS) before PSM; C: Kaplan-Meier curves based on PFS after PSM; D: Kaplan-Meier curves based on OS after PSM. PFS: Progression-free survival; OS: Overall survival; PSM: Propensity score matching; BeSiIT: Bevacizumab plus sintilimab plus interventional treatment; LeSiIT: Lenvatinib plus sintilimab plus interventional treatment.

Figure 3 Forest plot for progression-free survival and overall survival of the matched cohorts of patients. BeSiIT: Bevacizumab plus sintilimab plus interventional treatment; LeSiIT: Lenvatinib plus sintilimab plus interventional treatment; PFS: Progression-free survival; OS: Overall survival; HR: Hazard ratios; AFP: Α-fetoprotein; BCLC: The Barcelona Clinic Liver Cancer; ECOG PS: Eastern Cooperative Oncology Group Performance Status.

Figure 4 Best percentage changes in the sizes of the intrahepatic target lesions of patients from baseline assessed with modified response evaluation criteria in solid tumors. A: Bevacizumab plus sintilimab plus interventional treatment; B: Lenvatinib plus sintilimab plus interventional treatment. The horizontal coordinate represents each patient and the vertical coordinate represents the percentage change in intrahepatic target lesion size from baseline. BeSiIT: Bevacizumab plus sintilimab plus interventional treatment; LeSiIT: Lenvatinib plus sintilimab plus interventional treatment; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease.

Figure 5 Kaplan-Meier curves based on α-fetoprotein and carcinoembryonic antigen score. A: Kaplan-Meier curves based on progression-free survival (PFS); B: Kaplan-Meier curves based on overall survival (OS); C: Kaplan-Meier curves based on PFS in the bevacizumab plus sintilimab plus interventional treatment (BeSiIT) groups; D: Kaplan-Meier curves based on OS in the BeSiIT groups; E: Kaplan-Meier curves based on PFS in the lenvatinib plus sintilimab plus interventional treatment (LeSiIT) groups; F: Kaplan-Meier curves based on OS in the LeSiIT groups. AFCE: Α-fetoprotein and carcinoembryonic antigen score; PFS: Progression-free survival; OS: Overall survival.

Figure 6 Receiver operating characteristic curves for α-fetoprotein and carcinoembryonic antigen score in the bevacizumab plus sintilimab plus interventional treatment subgroup. AUC: Area under the curve.