Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth

Figure 1 Under the tumor microenvironment, abnormally activated wingless/integrated signaling pathway in cancer cells can be interpreted as an M2-tumor-associated macrophage polarization mediator. This figure was created with the assistance of Biorender. Wnt: Wingless/integrated; TAM: Tumor-associated macrophage; LRP5/6: Lipoprotein receptor-related proteins 5 and 6; GSK: Glycogen synthase kinase; CKIα: Casein kinase Ialpha; APC: Adnomatous polyposis coli; TCF: T-cell factor; LEF: Lymphoid enhancer-binding factor.