Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma

Figure 1 Selection of the variables of random forest model and the time dependence area under the curve of the models. A: Number of best trees and variable importance plots obtained from the random forest method for overall survival (OS); B: Number of best trees and variable importance plots obtained from the random forest method for recurrence free survival (RFS); C: The area under the curve (AUC) of 1, 3, and 5 years of the cox model for OS; D: The AUC of 1, 3, and 5 years of the cox model for RFS; E: The AUC of 1, 3, and 5 years of the forest model for OS; F: The AUC of 1, 3, and 5 years of the forest model for RFS. AFP: Alpha-fetoprotein; TTD: Total tumor diameter; VI: Vascular invasion; CK18: Cytokeratin-18; MTD: Maximum tumor diameter; DCP: Des-gamma-carboxy prothrombin; MI: Membrane invasion; GP73: Golgi protein 73; ML: Microsatellite lesions; AUC: Area under the curve.

Figure 2 The construction of the nomogram. A: The nomogram of predicting overall survival after liver transplantation (LT); B: The nomogram of predicting hepatocellular carcinoma recurrence free survival after LT. AFP: Alpha-fetoprotein; CK18: Cytokeratin-18; TTD: Total tumor diameter; VI: Vascular invasion; OS: Overall survival; RFS: Recurrence free survival.

Figure 3 Efficacy comparison of nomogram and existing criteria. A: The 3-year area under the curve (AUC) of nomogram and Milan, Hangzhou and UCSF for overall survival (OS); B: The 5-year AUC of nomogram and Milan, Hangzhou and UCSF for OS; C: The 3-year AUC of nomogram and Milan, Hangzhou, UCSF for recurrence free survival (RFS); D: The 5-year AUC of nomogram and Milan, Hangzhou, UCSF for RFS; E: The calibration curve of nomogram for OS; F: The calibration curve of nomogram for RFS. OS: Overall survival; RFS: Recurrence free survival.

Figure 4 Survival analysis of nomogram and clinical efficacy analysis. A: The survival curve for overall survival (OS); B: The survival curve for recurrence free survival (RFS); C: The decision curve analysis (DCA) curve for OS; D: The DCA curve for RFS.