Meta-Analysis
Copyright ©The Author(s) 2024.
World J Gastroenterol. May 7, 2024; 30(17): 2354-2368
Published online May 7, 2024. doi: 10.3748/wjg.v30.i17.2354
Figure 1
Figure 1 Scheme of the minocyclines’ mechanism of action. Amino acids and tRNAs are linked together by aminoacyl-tRNA synthetase to produce specific Aminoacyl-tRNAs. ribosomes on the ribosomal complex then read the code along the 5’-3’ direction of the mRNAs while linking various aminoacyl-tRNA-transported amino acids according to the instructions of the mRNA coding sequences for the process of protein synthesis. When minocycline enters into bacteria, it specifically binds to the A site of bacterial ribosomal 30S subunit aminoacyl group, thus blocking the aminoacyl-tRNA binding at this site, preventing peptide chain elongation and bacterial protein synthesis, and exerting bactericidal effects. AA: Amino acids.
Figure 2
Figure 2 Literature identification process.
Figure 3
Figure 3 Forest plots comparing eradication rates for intention-to-treat and per-protocol analyses of quadruple regimens with and without minocycline. CI: Confidence interval.
Figure 4
Figure 4 Forest plots comparing eradication rates for intention-to-treat and per-protocol analyses of quadruple regimens with and without minocycline-metronidazole. CI: Confidence interval.
Figure 5
Figure 5 Comparison of the incidence of adverse reactions of quadruple therapy and dizziness in quadruple therapy with and without minocycline. A: Comparison of the incidence of adverse reactions of quadruple therapy with and without minocycline; B: Comparison of the incidence of dizziness in quadruple therapy with and without minocycline. CI: Confidence interval.
Figure 6
Figure 6 Funnel plots of all included studies through intention-to-treat and per-protocol analyses. A: Intention-to-treat analyses; B: Per-protocol analyses.
Figure 7
Figure 7 Sensitivity analysis of all included studies by sequentially removing each study with intention-to-treat and per-protocol analyses. A: Intention-to-treat analyses; B: Per-protocol analyses. CI: Confidence interval.