Assessing recent recurrence after hepatectomy for hepatitis B-related hepatocellular carcinoma by a predictive model based on sarcopenia

Figure 1 Flowchart of patients. HCC: Hepatocellular carcinoma.

Figure 2 Predicting the probability of 1- and 2-yr recurrence-free survival in hepatocellular carcinoma patients at 1- and 2-yr after hepatectomy using a visualized SAMD model's nomogram (SAMD model: Sarcopenia, alpha-fetoprotein ≥ 40 ng/mL, the maximum diameter of tumor > 5 cm, and hepatitis B virus level ≥ 2000 IU/mL). A: Calibration plots of predicted 1- and 2-yr recurrence-free survival based on the cox regression model in the training and validation cohorts; B: Training cohort (a and b); validation cohort (c and d). AFP: Alpha-fetoprotein; RFS: Recurrence-free survival; HBV: Hepatitis B virus; SAMD: Based on the sarcopenia to assess the recurrence-free survival model of hepatectomy with hepatitis B-related liver cancer disease.

Figure 3 Comparison of receiver operating characteristic curves and recurrence-free survival rates between SAMD model and other models in predicting 2-year recurrence in hepatocellular carcinoma patients after hepatectomy. SAMD model [sarcopenia, alpha-fetoprotein (AFP) ≥ 40 ng/mL, the maximum diameter of tumor > 5 cm, and hepatitis B virus deoxyribonucleic acid level ≥ 2000 IU/mL]; assessment for surveillance interval score (age and international normalized ratio); pre-model of recurrence after liver transplantation (tumor size > 3 cm, AFP ≥ 200 ng/mL, and Neutrophil-to-lymphocyte ratio > 5); the pre-operative model, early recurrence after surgery for liver tumor: (Gender, albumin-bilirubin grade, AFP, tumor size, and tumor number). A: Receiver operating curve; B: Recurrence-free survival rates. pre-MORAL: Pre-model of recurrence after liver transplantation; ERASL-pre: The pre-operative model, early recurrence after surgery for liver tumor; AS: Assessment for Surveillance interval score; SAMD: Based on the sarcopenia to assess the recurrence-free survival model of hepatectomy with hepatitis B-related liver cancer disease.