Treat to target in Crohn’s disease: A practical guide for clinicians

Figure 1 A practical approach to evaluating response to new therapy using a treat-to-target approach. ¹Selecting Therapeutic Targets in Inflammatory Bowel Disease II endorsed treatment targets: Consider treatment modification if not met. PRO2: Patient reported outcome 2; CRP: C-reactive protein; FCP: Faecal calprotectin; IUS: Intestinal ultrasound.

Figure 2 A treat-to-target approach requires multidisciplinary care. IBD: Inflammatory bowel disease; T2T: Treat-to-target.

Figure 3 A practical approach to the clinical application of a treat-to-target strategy in clinical practice. ¹Selecting Therapeutic Targets in Inflammatory Bowel Disease II endorsed treatment target: Consider changing therapy if not met. ²Transmural healing is an adjuvant to endoscopic remission. HBI: Harvey Bradshaw Index; PROM: Patient reported outcome measure; PRO2: Patient reported outcome 2; QoL: Quality of life; AP: Abdominal pain; SF: Stool frequency; CRP: C-reactive protein; ULN: Upper limit of normal; FCP: Faecal calprotectin; SES-CD: Simple Endoscopic Score for Crohn’s Disease; CDEIS: Crohn's Disease Endoscopic Index of Severity; IUS: Intestinal ultrasound; MRE: Magnetic resonance enterography.