Changes in p53 and Waf1p21 expression and cell proliferation in esophageal carcinogenesis

Figure 1 Changes in p53 and Waf1p21 expression in normal esophageal epithelia and epithelia with different degrees of lesions. As the lesions progressed from BCH, DYS to SCC, the number of p53- and PCNA-positive cells significantly increased. In contrast, the number of Waf1p21-positive cells slightly increased from normal to BCH, but there was no further increase in DYS and in SCC. SCC: Squamous cell carcinoma; DYS: Dysplasia; BCH: Basal cell hyperplasia.

Figure 2 Waf1p21 immunostaining in biopsy samples of esophageal BCH. Waf1p21-positive cells localized to the third and fourth cell epithelial layers (arrow). Scale bar, 2.4 μm. BCH: Basal cell hyperplasia.