Different oncological features of colorectal cancer codon-specific KRAS mutations: Not codon 13 but codon 12 have prognostic value

Figure 1 Incidence of microsatellite instability status and Kirsten rat sarcoma viral oncogene homolog mutations. A: Microsatellite instability status; B: Mutations of the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene in relation to baseline characteristics. KRAS: Kirsten rat sarcoma viral oncogene homolog; MSS: Microsatellite stable; MSI: Microsatellite instability.

Figure 2 Comparative survival analysis between colorectal cancer samples with wild-type and Kirsten rat sarcoma viral oncogene homolog mutation. Blue lines indicate wild-type Kirsten rat sarcoma viral oncogene homolog (KRAS). Other lines represent codon-specific KRAS mutations of codon 12 (red), 13 (green), and 61 (orange). A: Recurrence-free survival; B: Overall survival rates were compared using a log-rank test. WT: Wild-type; MT: Mutation.

Figure 3 Survival analysis of each codon-specific Kirsten rat sarcoma viral oncogene homolog mutation in colorectal cancer. Colored lines indicate codon-specific Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. A: The red line indicates the recurrence-free survival (RFS) of patients with KRAS codon 12 mutations; B: The green line indicates the RFS of patients with KRAS codon 13 mutations; C: The orange line indicates the RFS of patients with KRAS codon 61 mutations. MT: Mutation.