SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia: A long-term study

Figure 1 Study flow chart. ESD: Endoscopic submucosal dissection; LIN: Low-grade intraepithelial neoplasia; SM2: Penetration of the submucosal layer > 200 μm from the muscularis mucosa; ESCN: Esophageal squamous cell neoplasia; ESCC: Esophageal squamous cell carcinoma; EP: Epithelium; SM1: Penetration of the submucosal layer < 200 μm or 200 μm from the muscularis mucosa; SGK3: Serum and glucocorticoid-induced protein kinase 3.

Figure 2 Serum and glucocorticoid-induced protein kinase 3 protein expression in superficial esophageal squamous cell neoplasia (magnification: × 400). A: No serum and glucocorticoid-induced protein kinase 3 (SGK3) expression in esophageal squamous cell neoplasia (ESCN) samples (normal for SGK3 overexpression; 0); B: Weak SGK3 expression in ESCN samples (normal for SGK3 overexpression; 1+); C: Moderate SGK3 expression in ESCN samples (positive for SGK3 overexpression; 2+); D: Strong SGK3 expression in ESCN samples (positive for SGK3 overexpression; 3+).

Figure 3 Kaplan-Meier curves for overall survival and disease-free survival. A: Overall survival; B: Disease-free survival.