Liver histopathological lesions is severe in patients with normal alanine transaminase and low to moderate hepatitis B virus DNA replication

Figure 1 Flow diagram of enrolled patients. ALB: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; HBeAg: Hepatitis B e antigen; L: Lymphocyte; N: Neutrophils; WBC: White blood cell; HBV: Hepatitis B virus; ULN: Upper limit of normal.

Figure 2 Liver pathological changes among 634 patients with normal alanine transaminase at different hepatitis B virus DNA levels. A: Necroinflammatory activity grading among patients at different hepatitis B virus (HBV) DNA levels; B: Liver fibrosis staging among patients at different HBV DNA levels; C: Liver histopathological severity ≥ A2 or/and ≥ F2 among patients at different HBV DNA levels. A: Liver inflammatory activity; F: Liver fibrosis; CMA: Chinese Medical Association; EASL: European Association for the Study of the Liver.

Figure 3 Prediction probabilities (PRE_) of the binary logistic regression model. A: < A2 vs ≥ A2; B: < F2 vs ≥ F2; C: < A2 and < F2 vs ≥ A2 or/and ≥ F2). A: Liver inflammatory activity; F: Liver fibrosis.