Chinese herbal formula shen-ling-bai-zhu-san to treat chronic gastritis: Clinical evidence and potential mechanisms

Figure 1 Flowchart of database searching and study identification.

Figure 2 Risk of bias summary.

Figure 3 Forest plot. A: Forest plot for total effectiveness; B: Forest plot for recurrence rate; C: Forest plot for the reversal rate of Helicobacter pylori positivity. 95%CI: 95% confidence interval.

Figure 4 Funnel plot and network. A: Funnel plot of total effectiveness rate; B: Network plot of the active compounds of Shen-ling-bai-zhu san (SLBZS) target and chronic gastritis (CG) target; C: SLBZS-CG target protein interaction network.

Figure 5 GO analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. A: GO analysis of the critical targets of Shen-ling-bai-zhu san (SLBZS) in treatment for chronic gastritis (CG); B: Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the critical targets of SLBZS in treatment for CG.

Figure 6 Schematic diagram. A: Schematic diagram of main Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, EGFR tyrosine kinase inhibitor resistance; B: Schematic diagram of the main KEGG pathways, PI3K-AKT signaling pathway, arrows represent activation effect, T-arrows represent inhibition effect, and segments show activation or inhibition effects.