Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer

doi:10.3748/wjg.v28.i33.4744

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Sep 7, 2022 (publication date) through May 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2022; 28(33): 4744-4761
Published online Sep 7, 2022. doi: 10.3748/wjg.v28.i33.4744

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Figure 1 Representation of individual colorectal cancer subtypes.

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Figure 2 Three genetic and epigenetic aberrations of colorectal cancer formation. LOH: Loss of heterozygosity; TGF: Transforming growth factor.

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Figure 3 Transforming growth factor-beta superfamily signal transduction. TGF: Transforming growth factor; EMT: Epithelial-mesenchymal transition; ERK: Extracellular signal-regulated kinase; BMP: Bone morphogenetic protein; SMAD: Small mothers against decapentaplegic homolog.

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Figure 4 Inhibitory effect of small mothers against decapentaplegic homolog 7 on the process of colorectal cancer development. TGF: Transforming growth factor; SMAD: Small mothers against decapentaplegic homolog.

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Figure 5 Inhibition strategies of transforming growth factor-β signaling pathway and miRNAs targets for colorectal cancer treatment. TGF: Transforming growth factor; SMAD: Small mothers against decapentaplegic homolog.

Citation: Maslankova J, Vecurkovska I, Rabajdova M, Katuchova J, Kicka M, Gayova M, Katuch V. Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer. World J Gastroenterol 2022; 28(33): 4744-4761
URL: https://www.wjgnet.com/1007-9327/full/v28/i33/4744.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i33.4744