Colon mucus in colorectal neoplasia and beyond

doi:10.3748/wjg.v28.i32.4475

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2022; 28(32): 4475-4492
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4475

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Figure 1 Schematic representation of normal human colonic mucosa and overlaying mucus layers. Small green arrows show short-chain fatty acid transport through colon mucus layers. Small black shapes show bacteria. CMP: Colon mucus plumes; MUC2: Mucins 2; SCFA: Short-chain fatty acids.

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Figure 2 Scheme of colorectal mucus-associated events involved in colorectal cancer development. BBF: Bacterial biofilm; Exf: Exfoliated malignant cells of colorectal cancer; GC: Goblet cells; Neu: Neutrophils; Eos: Eosinophils; Mp: Macrophages; Er: Erythrocytes; DC: Dendritic cells; PC: Plasma cells; Ly: Lymphocytes; Fb: Fibroblasts; ET-osis: Extracellular DNA trap formation; NET-osis: ET-osis exerted by neutrophils; EET-osis: ET-osis exerted by eosinophils. Small black shapes show bacteria; CRC: Colorectal cancer.

Citation: Loktionov A. Colon mucus in colorectal neoplasia and beyond. World J Gastroenterol 2022; 28(32): 4475-4492
URL: https://www.wjgnet.com/1007-9327/full/v28/i32/4475.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i32.4475