Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients

Figure 1 Flow diagram of the study population. A total of 528 patients with T1bN0M0 gallbladder cancer were included in this study.SEER: Surveillance, Epidemiology, and End Results database; AJCC: American Joint Committee on Cancer; TNM: Tumor-node-metastasis; GBC: Gallbladder cancer; N: Number.

Figure 2 Overall survival and disease-specific survival of 528 patients with T1b gallbladder cancer who received different surgical treatment assessed using Kaplan-Meier analysis, and the proportions of different surgical approaches. A: Overall survival of patients with T1b gallbladder cancer (GBC) received simple cholecystectomy (SC), SC with lymph node resection (SC + LN), or radical cholecystectomy (RC) (P < 0.001); B: Disease-specific survival of patients with T1b GBC who received SC, SC + LN, or RC (P = 0.003); C: The proportions of different surgical approaches in patients with different pathological grades of gallbladder cancer. SC: Simple cholecystectomy; LN: Lymph node resection; RC: Radical cholecystectomy.

Figure 3 The overall survival and disease-specific survival of patients with T1b gallbladder cancer stratified by pathological grades and surgical treatment using Kaplan-Meier analysis. A: Overall survival (OS) of patients with grade I T1b gallbladder cancer (GBC) by type of surgery (P = 0.734); B: Disease-specific survival (DSS) of patients with grade I T1b GBC by type of surgery (P = 0.953); C: OS of patients with grade II T1b GBC by type of surgery (P = 0.002); D: DSS of patients with grade II T1b GBC by type of surgery (P = 0.039); E: OS of patients with grade III, IV T1b GBC by type of surgery (P = 0.005); F: DSS of patients with grade III, IV T1b GBC by type of surgery (P = 0.009). SC: Simple cholecystectomy; LN: Lymph node resection; RC: Radical cholecystectomy.