c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions

Figure 1 Expression intensity of c-MET in sporadic colonic lesions. A: Semi-quantitative assessment of c-MET expression intensity throughout sporadic colorectal carcinogenesis; B: Representative photomicrograph of normal colonic mucosa; C: Representative photomicrograph of hyperplastic polyp; D: Representative photomicrograph of sessile serrated lesion; E: Representative photomicrograph of tubular/tubulovillous adenoma with low grade dysplasia; F: Representative photomicrograph of tubular/tubulovillous adenoma with high grade dysplasia; G: Representative photomicrograph of sporadic colorectal adenocarcinoma. Tissue provided by Lothian NRS Bioresource. Brightfield photomicrographs taken at X20 magnification. TA-LGD: Tubular/tubulovillous adenoma with low grade dysplasia; TA-HGD: Tubular/tubulovillous adenoma with high grade dysplasia; s-CRC: Sporadic colorectal adenocarcinoma; HP: Hyperplastic polyp; SSL: Sessile serrated lesion.

Figure 2 Expression intensity of c-MET in inflammatory bowel disease-associated lesions. A: Semi-quantitative assessment of c-MET expression intensity throughout inflammatory bowel disease (IBD)-associated colorectal carcinogenesis; B: Representative photomicrograph of quiescent IBD mucosa; C: Representative photomicrograph of active/inflamed IBD mucosa; D: Representative photomicrograph of IBD-associated dysplastic lesions; E: Representative photomicrograph of IBD-associated colorectal cancer. Tissue provided by Lothian NRS Bioresource. Brightfield photomicrographs taken at X20 magnification. IBD: Inflammatory bowel disease; CRC: Colorectal cancer.