Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats

Figure 1 Histological changes in various groups of rats. HE staining, magnification: 400 ×. A: Normal control group; B: Model control group; C: Fuzi-Gancao (F-G) group (15 g/kg); D: F-G group (30 g/kg); E: Positive control group (silybin).

Figure 2 Serum metabolites in rats. A: Partial Least-Squares Discriminant Analysis; B: P-test analysis. M: Model control group; N: Negative control group; F-G: Fuzi-Gancao group.

Figure 3 Metabolic pathway analysis of serum in rats. A: Negative control group vs model control group; B: Fuzi-Gancao group vs model control group.

Figure 4 Bile acids in rats (n = 6, mean ± SD). ^aP < 0.05, ^bP < 0.01 for each treatment group and model control group, respectively; ^cP < 0.05, ^dP < 0.01 for the model control group and normal control group, respectively.

Figure 5 Bile acids in rats. A: Partial Least-Squares Discriminant Analysis; B: P-test analysis.