Quinone oxidoreductase 1 is overexpressed in gastric cancer and associated with outcome of adjuvant chemotherapy and survival

Figure 1 Western blot analysis of quinine oxidoreductase 1 expression in gastric carcinoma cell line AGS. Protein extracts from AGS human gastric cancer cells were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and the proteins were detected by Western blot using anti-quinine oxidoreductase 1 antibodies. Molecular masses in kDa are indicated to the left. NQO1: Quinine oxidoreductase 1.

Figure 2 Representative images of immunohistochemical staining for quinine oxidoreductase 1 in gastric cancer samples. A: Strong (+++); B: Moderate (++); C: Weak (+); D: Negative staining (original magnification × 400).

Figure 3 Kaplan-Meier survival curves of postoperative outcomes of gastric cancer patients according to quinine oxidoreductase 1 expression status. The correlation of high and low quinine oxidoreductase 1 expression with the overall survival rate was statistically significant (P = 0.02). NQO1: Quinine oxidoreductase 1; OS: Overall survival; CI: Confidence interval.

Figure 4 Kaplan-Meier analysis of overall survival rates in patients with gastric cancer. A: Low oxidoreductase 1 expression; B: High quinine oxidoreductase 1 expression; C: Surgery only; D: With adjuvant chemotherapy. NQO1: Quinine oxidoreductase 1.