Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome

Figure 1 Response to faecal microbiota transplantation in females and males at different intervals after faecal microbiota transplantation in the two groups. A: Placebo group; B: Active treated group.

Figure 2 Response rates to faecal microbiota transplantation of female and male irritable bowel syndrome patients. A: Irritable bowel syndrome with diarrhoea-predominant; B: Irritable bowel syndrome with constipation-predominant; C: Irritable bowel syndrome with mixed diarrhoea and constipation. ^cP < 0.001. FMT: Faecal microbiota transplantation.

Figure 3 Response rates to faecal microbiota transplantation and the total irritable bowel syndrome-severity scoring system scores of irritable bowel syndrome patients with moderate irritable bowel syndrome symptoms (irritable bowel syndrome-severity scoring system total score between 175 and 300) and with severe irritable bowel syndrome symptoms (irritable bowel syndrome-severity scoring system total score of ≥ 300). A: Faecal microbiota transplantation; B: Irritable bowel syndrome severity scoring system total score. MS: Moderate irritable bowel syndrome symptoms; SS: Severe irritable bowel syndrome symptoms; FMT: Faecal microbiota transplantation.

Figure 4 The total irritable bowel syndrome-severity scoring system scores in females and males. A: Placebo group; B: Active treated group. FMT: Faecal microbiota transplantation.

Figure 5 The total irritable bowel syndrome-severity scoring system scores in females and males. A: Irritable bowel syndrome with diarrhoea-predominant; B: Irritable bowel syndrome with constipation-predominant; C: Irritable bowel syndrome with mixed diarrhoea and constipation. ^aP < 0.05. IBD-SSS: Irritable bowel syndrome-severity scoring system; FMT: Faecal microbiota transplantation.

Figure 6 The total Fatigue Assessment Scale scores in female and male irritable bowel syndrome patients. A: Placebo group; B: Active treated group. ^aP < 0.05. FAS: Fatigue Assessment Scale; FMT: Faecal microbiota transplantation.

Figure 7 Total Fatigue Assessment Scale scores in female and male patients. A: Irritable bowel syndrome with diarrhoea-predominant; B: Irritable bowel syndrome with constipation-predominant; C: Irritable bowel syndrome with mixed diarrhoea and constipation. FAS: Fatigue Assessment Scale; FMT: Faecal microbiota transplantation.

Figure 8 Total irritable bowel syndrome quality of life scale scores in female and male patients. A: Placebo group; B: Active treated group. ^aP < 0.05. IBS-QoL: Irritable bowel syndrome quality of life scale; FMT: Faecal microbiota transplantation.

Figure 9 Total irritable bowel syndrome quality of life scale scores in females and males. A: Irritable bowel syndrome with diarrhoea-predominant; B: Irritable bowel syndrome with constipation-predominant; C: Irritable bowel syndrome with mixed diarrhoea and constipation. IBS-QoL: Irritable bowel syndrome quality of life scale; FMT: Faecal microbiota transplantation.

Figure 10  Bacteria levels in the faeces of female and male irritable bowel syndrome patients in the placebo group at the baseline and 1 mo after faecal microbiota transplantation. A: Baseline; B: 1 mo after faecal microbiota transplantation. The bacterial levels are relative values to a normobiotic microbiota profile of 165 healthy subjects. FMT: Faecal microbiota transplantation.

Figure 11  Faecal bacteria levels in the female and male irritable bowel syndrome patients in the active treated group at the baseline and 1 mo after faecal microbiota transplantation. A: Baseline; B: 1 mo after faecal microbiota transplantation. The bacterial levels are expressed as in Figure 10. FMT: Faecal microbiota transplantation.

Figure 12  The faecal short chain fatty acids concentration of female and male patients in both the placebo and active treated groups at the baseline and 1 mo after faecal microbiota transplantation. The values were expressed as mmol/kg wet weight (mean ± SD).